Technology Process of C35H42N6O5
There total 9 articles about C35H42N6O5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diethylzinc / hexane; toluene / 1 h / Inert atmosphere; Reflux
1.2: 1 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / toluene / Inert atmosphere
3.1: water; calcium carbonate; methyl iodide / acetonitrile / 17 h
4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.33 h
5.1: trifluoroacetic acid / dichloromethane / 9 h / 0 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
7.1: potassium fluoride / water; N,N-dimethyl-formamide / 0.08 h
8.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24.5 h / 20 °C / Inert atmosphere
With
potassium fluoride; sodium chlorite; copper(l) iodide; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; water; diethylzinc; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; calcium carbonate; diethylazodicarboxylate; methyl iodide;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
2.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.05.012
- Guidance literature:
-
Multi-step reaction with 6 steps
1: water; calcium carbonate; methyl iodide / acetonitrile / 17 h
2: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.33 h
3: trifluoroacetic acid / dichloromethane / 9 h / 0 °C
4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
5: potassium fluoride / water; N,N-dimethyl-formamide / 0.08 h
6: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24.5 h / 20 °C / Inert atmosphere
With
potassium fluoride; sodium chlorite; copper(l) iodide; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; calcium carbonate; methyl iodide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tet.2011.05.012
- Guidance literature:
-
Multi-step reaction with 7 steps
1: triphenylphosphine; diethylazodicarboxylate / toluene / Inert atmosphere
2: water; calcium carbonate; methyl iodide / acetonitrile / 17 h
3: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.33 h
4: trifluoroacetic acid / dichloromethane / 9 h / 0 °C
5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
6: potassium fluoride / water; N,N-dimethyl-formamide / 0.08 h
7: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24.5 h / 20 °C / Inert atmosphere
With
potassium fluoride; sodium chlorite; copper(l) iodide; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; calcium carbonate; diethylazodicarboxylate; methyl iodide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.05.012