C₂₆H₄₀N₄O₂

Base Information

• Chemical Name: C₂₆H₄₀N₄O₂
• CAS No.: 1414356-81-2
• Molecular Formula: C₂₆H₄₀N₄O₂
• Molecular Weight: 440.629
• Mol file: 1414356-81-2.mol

Synonyms:

Chemical Property of C₂₆H₄₀N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₄₀N₄O₂

There total 18 articles about C₂₆H₄₀N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5.5-dimethyl-1,3,2-dioxathiane-2-oxide (1003-85-6) → C26H40N4O2 (1414356-81-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium periodate; ruthenium trichloride / dichloromethane; water; acetonitrile / 20 °C

2.1: N,N-dimethyl-formamide / 20 °C

2.2: 80 °C

3.1: potassium hydride / N,N-dimethyl-formamide; mineral oil / 160 °C

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / -75 - 20 °C

5.1: titanium(IV) tetraethanolate / tetrahydrofuran / 60 °C

6.1: sodium tetrahydroborate / tetrahydrofuran; water / 0 °C

7.1: methanol; hydrogenchloride / 1,4-dioxane / 20 °C

8.1: ethanol / 60 °C

9.1: 20 °C / Acidic conditions

10.1: dichloromethane / 20 °C

With hydrogenchloride; methanol; ruthenium trichloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; sodium periodate; ethanol; tert.-butyl lithium; potassium hydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; pentane;

DOI:10.1016/j.bmcl.2012.08.097

Reference yield:

5,5-dimethyl-1,3,2-dioxathiane-2,2-dioxide (1755-97-1) → C26H40N4O2 (1414356-81-2)

Guidance literature:

Multi-step reaction with 10 steps

1: N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / water / 80 °C

3: potassium hydride / N,N-dimethyl-formamide; mineral oil / 160 °C

4: tert.-butyl lithium / tetrahydrofuran; pentane / -75 - 20 °C

5: titanium(IV) tetraethanolate / tetrahydrofuran / 60 °C

6: sodium tetrahydroborate / tetrahydrofuran; water / 0 °C

7: methanol; hydrogenchloride / 1,4-dioxane / 20 °C

8: ethanol / 60 °C

9: 20 °C / Acidic conditions

10: dichloromethane / 20 °C

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; sodium tetrahydroborate; ethanol; tert.-butyl lithium; potassium hydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; pentane;

DOI:10.1016/j.bmcl.2012.08.097

Reference yield:

2,2-Dimethyl-1,3-propanediol (126-30-7) → C26H40N4O2 (1414356-81-2)

Guidance literature:

Multi-step reaction with 11 steps

1.1: thionyl chloride / dichloromethane / 0 - 20 °C

2.1: sodium periodate; ruthenium trichloride / dichloromethane; water; acetonitrile / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

3.2: 80 °C

4.1: potassium hydride / N,N-dimethyl-formamide; mineral oil / 160 °C

5.1: tert.-butyl lithium / tetrahydrofuran; pentane / -75 - 20 °C

6.1: titanium(IV) tetraethanolate / tetrahydrofuran / 60 °C

7.1: sodium tetrahydroborate / tetrahydrofuran; water / 0 °C

8.1: methanol; hydrogenchloride / 1,4-dioxane / 20 °C

9.1: ethanol / 60 °C

10.1: 20 °C / Acidic conditions

11.1: dichloromethane / 20 °C

With hydrogenchloride; methanol; ruthenium trichloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; sodium periodate; thionyl chloride; ethanol; tert.-butyl lithium; potassium hydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; pentane;

DOI:10.1016/j.bmcl.2012.08.097

upstream raw materials:

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

2,2-Dimethyl-1,3-propanediol

5.5-dimethyl-1,3,2-dioxathiane-2-oxide

5,5-dimethyl-1,3,2-dioxathiane-2,2-dioxide

Refernces