etidronate disodium

Base Information

• Chemical Name: etidronate disodium
• CAS No.: 32573-98-1
• Molecular Formula: C₂H₆O₇P₂*2Na
• Molecular Weight: 249.993
• Mol file: 32573-98-1.mol

Synonyms:

Chemical Property of etidronate disodium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of etidronate disodium

There total 9 articles about etidronate disodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

acetic acid (64-19-7,77671-22-8) → etidronate disodium (2666-14-0,3794-83-0,7414-83-7,13529-88-9,13710-39-9,17721-68-5,29329-71-3,32573-98-1)

Guidance literature:

acetic acid; With methanesulfonic acid; bis(trichloromethyl) carbonate; at 85 ℃; for 6h;

In water; at 105 ℃; for 4h;

With sodium hydroxide; In water; pH=1.8; Reagent/catalyst;

DOI:10.2174/15701808113109990026

Reference yield: 43.0%

acetyl chloride (75-36-5) → etidronate disodium (2666-14-0,3794-83-0,7414-83-7,13529-88-9,13710-39-9,17721-68-5,29329-71-3,32573-98-1)

Guidance literature:

acetyl chloride; With methanesulfonic acid; phosphorus trichloride; at 85 ℃; for 24h;

In water; at 105 ℃; for 4h;

With sodium hydroxide; In water; pH=1.8; Reagent/catalyst;

DOI:10.2174/15701808113109990026

Reference yield:

(2-hydroxyethyl)(methyl)amine (109-83-1) + 1-hydroxyethylene-(1,1-diphosphonic acid) (2809-21-4) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → etidronate disodium (2666-14-0,3794-83-0,7414-83-7,13529-88-9,13710-39-9,17721-68-5,29329-71-3,32573-98-1) + (1-hydroxyethylidene)bisphosphonic acid mono(2,6-dihydroxy-4-methyl-4-azahexyl) ester + {1-[(3-Chloro-2-hydroxy-propoxy)-hydroxy-phosphoryl]-1-hydroxy-ethyl}-phosphonic acid mono-(3-chloro-2-hydroxy-propyl) ester

Guidance literature:

Multistep reaction; 1.) water, 60 deg C, 20-30 h, pH 6-7;

upstream raw materials:

(2-hydroxyethyl)(methyl)amine

1-hydroxyethylene-(1,1-diphosphonic acid)

epichlorohydrin

ethanolamine

Downstream raw materials:

vinylidene-1,1-diphosphonic acid

Refernces

• 1、 Ito, Naoya,Hashizuka, Takahiko,Ito, Masataka,Suzuki, Hironori,Noguchi, Shuji. "Investigation of Physical Properties of Disodium Etidronate Tetrahydrate and Application of Phosphorus K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy". . p. 2147 - 2155. Retrieved 2021/12/22.
• 2、 -. "METHOD FOR PRODUCING PURE DISODIUM PAMIDRONATE". Page/Page column 10. . Retrieved 2008/06/13.