5-Bromo-4-nitro-1H-imidazole

Base Information

• Chemical Name: 5-Bromo-4-nitro-1H-imidazole
• CAS No.: 6963-65-1
• Molecular Formula: C3H2BrN3O2
• Molecular Weight: 191.972
• Hs Code.: 2933290090
• Mol file: 6963-65-1.mol

Synonyms:1H-Imidazole,4-bromo-5-nitro- (9CI);Imidazole, 4-bromo-5-nitro- (8CI);4-Nitro-5-bromoimidazole;5(4)-Bromo-4(5)-nitroimidazole;5-Bromo-4-nitro-1H-imidazole;5-Bromo-4-nitroimidazole;NSC 54255;

Chemical Property of 5-Bromo-4-nitro-1H-imidazole

Chemical Property:

• Vapor Pressure: 1.06E-05mmHg at 25°C
• Melting Point: 281-282℃ (DEC.)
• Refractive Index: 1.663
• Boiling Point: 382.2 °C at 760 mmHg
• PKA: 5.60±0.10(Predicted)
• Flash Point: 184.9 °C
• PSA: 74.50000
• Density: 2.156 g/cm³
• LogP: 1.60360
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-4-nitro-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-4-nitro-1H-imidazole

There total 7 articles about 5-Bromo-4-nitro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-bromo-1H-imidazole (2302-25-2) → 5-bromo-4-nitro-1H-imidazole (6963-65-1)

Guidance literature:

With sulfuric acid; nitric acid; In ethanol;

DOI:10.1021/ol036188j

Reference yield: 87.0%

4-bromo-1 H-imidazole (2302-25-2) → 5-bromo-4-nitro-1H-imidazole (6963-65-1)

Guidance literature:

With nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid;

Reference yield: 81.0%

4-Iodo-5-nitroimidazole (76529-48-1) → 4-bromo-5-nitro-1H-imidazole (6963-65-1)

Guidance literature:

With hydrogen bromide; for 0.333333h; Heating;

DOI:10.1021/jo00322a005

upstream raw materials:

4-Iodo-5-nitroimidazole

5-nitro-1H-imidazole

sulfuric acid

4-bromo-1 H-imidazole

Downstream raw materials:

4-bromo-1-methyl-5-nitro-1H-imidazole

2,4⁽⁵⁾-dibromo-5⁽⁴⁾-nitroimidazole

5-bromo-4-nitro-1-phenacylimidazole

4-Bromo-5-nitro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole

Refernces

• 1、 Samant, Bhupesh S.,Sukhthankar, Mugdha G.. "Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis". supporting information; experimental part. p. 1015 - 1018. Retrieved 2011/03/21.
• 2、 -. "Anti-infective agents". Page 122-123. . Retrieved 2010/02/06.