4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride

Base Information

• Chemical Name: 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride
• CAS No.: 1229236-88-7
• Molecular Formula: C₁₉H₁₉Cl₂FN₄O*ClH
• Molecular Weight: 445.751
• Mol file: 1229236-88-7.mol

Synonyms:

Chemical Property of 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride

There total 7 articles about 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol (1229236-84-3) → 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride (1229236-88-7)

Guidance literature:

(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol; With trifluoroacetic acid; In toluene; at 80 ℃;

With hydrogenchloride; In water; toluene;

DOI:10.1021/op200229j

Reference yield:

(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide (1229236-79-6) → 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride (1229236-88-7)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium bromide / N,N-dimethyl-formamide / 30 h / 35 °C / Inert atmosphere; Large scale reaction

2: ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid / water; acetonitrile / 70 °C / Large scale reaction

3: hydrogenchloride; acetic acid / 100 °C

4: sodium tetrahydroborate / methanol / 5 °C

5: potassium carbonate / water / 80 °C

6: trifluoroacetic acid / toluene / 80 °C

With hydrogenchloride; ammonium peroxydisulfate; sodium tetrahydroborate; potassium carbonate; silver nitrate; acetic acid; trifluoroacetic acid; sodium bromide; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Finkelstein reaction / 2: Minisci reaction;

DOI:10.1021/op200229j

Reference yield:

4’-chloro-2’-fluoroacetophenone (175711-83-8) → 4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine hydrochloride (1229236-88-7)

Guidance literature:

Multi-step reaction with 7 steps

1: sulfuryl dichloride / methanol; dichloromethane / 7 h / -5 - 0 °C / Large scale reaction

2: sodium bromide / N,N-dimethyl-formamide / 30 h / 35 °C / Inert atmosphere; Large scale reaction

3: ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid / water; acetonitrile / 70 °C / Large scale reaction

4: hydrogenchloride; acetic acid / 100 °C

5: sodium tetrahydroborate / methanol / 5 °C

6: potassium carbonate / water / 80 °C

7: trifluoroacetic acid / toluene / 80 °C

With hydrogenchloride; ammonium peroxydisulfate; sodium tetrahydroborate; sulfuryl dichloride; potassium carbonate; silver nitrate; acetic acid; trifluoroacetic acid; sodium bromide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2: Finkelstein reaction / 3: Minisci reaction;

DOI:10.1021/op200229j

upstream raw materials:

(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol

(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide

(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo-[1,2-b]pyridazin-3-yl)methanone

4’-chloro-2’-fluoroacetophenone

Refernces