Technology Process of 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester
There total 3 articles about 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 3-hydroxy-3-(prop-2-yn-1-yl)piperidine-1-carboxylate;
With
methanesulfonic acid; 3,5-dicholoropyridine N-oxide;
In
1,2-dichloro-ethane;
Inert atmosphere;
With
[bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I);
In
1,2-dichloro-benzene;
for 4h;
Inert atmosphere;
DOI:10.1021/jo400077m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: zinc/copper couple / tetrahydrofuran; toluene / 0.17 h / 0 °C / Sonication; Inert atmosphere
1.2: Inert atmosphere
2.1: 3,5-dicholoropyridine N-oxide; methanesulfonic acid / 1,2-dichloro-ethane / Inert atmosphere
2.2: 4 h / Inert atmosphere
With
methanesulfonic acid; 3,5-dicholoropyridine N-oxide; zinc/copper couple;
In
tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo400077m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate; water / methanol / 2.5 h / 20 °C
2.1: 3,5-dicholoropyridine N-oxide; methanesulfonic acid / 1,2-dichloro-ethane / Inert atmosphere
2.2: 4 h / Inert atmosphere
With
methanesulfonic acid; 3,5-dicholoropyridine N-oxide; water; potassium carbonate;
In
methanol; 1,2-dichloro-ethane;
DOI:10.1021/jo400077m
