4-phenoxymethylphenyl isocyanate

Base Information

• Chemical Name: 4-phenoxymethylphenyl isocyanate
• CAS No.: 74119-28-1
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.247
• Mol file: 74119-28-1.mol

Synonyms:

Chemical Property of 4-phenoxymethylphenyl isocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-phenoxymethylphenyl isocyanate

There total 4 articles about 4-phenoxymethylphenyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + phenyl 4-aminobenzyl ether (57181-90-5) → 4-phenoxymethylphenyl isocyanate (74119-28-1)

Guidance literature:

In toluene;

Reference yield:

4-phenoxymethyl-benzoic acid (31719-76-3) → 4-phenoxymethylphenyl isocyanate (74119-28-1)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In benzene; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo300400q

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → 4-phenoxymethylphenyl isocyanate (74119-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 16 h / 23 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

2.2: -78 - 23 °C / Inert atmosphere

3.1: diphenyl phosphoryl azide; triethylamine / benzene / 2 h / 80 °C / Inert atmosphere

With n-butyllithium; diphenyl phosphoryl azide; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1021/jo300400q

upstream raw materials:

phosgene

phenyl 4-aminobenzyl ether

4-phenoxymethyl-benzoic acid

1-bromomethyl-4-bromobenzene

Downstream raw materials:

(4-phenoxymethylphenyl)carbamic acid allyl ester

Refernces

• 1、 -. "N'-phenyl-N-methylurea derivatives". . . Retrieved 2008/06/13.