Technology Process of (S)-N-(3-(3-aminopiperidin-1-yl)pyridin-4-yl)-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine
There total 10 articles about (S)-N-(3-(3-aminopiperidin-1-yl)pyridin-4-yl)-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogen iodide / water / 1.5 h / 100 °C
2: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / tetrahydrofuran / 1 h / 60 °C
3: trichloroisocyanuric acid / 1,2-dichloro-ethane / 1.5 h / 90 °C
4: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C
5: trimethylphosphane / tetrahydrofuran / 3 h / 0 - 20 °C
6: hydrogenchloride / water; ethyl acetate / 20 °C
With
hydrogenchloride; sodium azide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); trichloroisocyanuric acid; hydrogen iodide; trimethylphosphane;
In
tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
2: |Negishi Coupling / 5: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2016.09.067
- Guidance literature:
-
Multi-step reaction with 5 steps
1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / tetrahydrofuran / 1 h / 60 °C
2: trichloroisocyanuric acid / 1,2-dichloro-ethane / 1.5 h / 90 °C
3: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C
4: trimethylphosphane / tetrahydrofuran / 3 h / 0 - 20 °C
5: hydrogenchloride / water; ethyl acetate / 20 °C
With
hydrogenchloride; sodium azide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); trichloroisocyanuric acid; trimethylphosphane;
In
tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
1: |Negishi Coupling / 4: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2016.09.067