5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt

Base Information

• Chemical Name: 5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt
• CAS No.: 1613021-12-7
• Molecular Formula: C₂HF₃O₂*C₂₂H₂₀N₆O
• Molecular Weight: 498.464
• Mol file: 1613021-12-7.mol

Synonyms:

Chemical Property of 5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt

There total 7 articles about 5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H20N6O (1613021-11-6) + trifluoroacetic acid (76-05-1) → 5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt (1613021-12-7)

Guidance literature:

In water; acetonitrile;

Reference yield:

(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-amine dihydrochloride → 5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt (1613021-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dimethyl sulfoxide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 0.5 h / 100 °C / Inert atmosphere; Sealed tube

3: water; acetonitrile

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

5-bromo-2-pyrimidinecarboxylic acid (37131-87-6) → 5-phenyl-N-[(3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-yl]pyrimidine-2-carboxamide trifluoroacetate salt (1613021-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dimethyl sulfoxide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 0.5 h / 100 °C / Inert atmosphere; Sealed tube

3: water; acetonitrile

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; dimethyl sulfoxide; toluene; acetonitrile;

upstream raw materials:

C₂₂H₂₀N₆O

trifluoroacetic acid

(S)-5-bromo-N-(1-(pyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl)pyrimidine-2-carboxamide

phenylboronic acid

Refernces