4-(3',4'-dimethoxyphenyl)-3-hexnone

Base Information

• Chemical Name: 4-(3',4'-dimethoxyphenyl)-3-hexnone
• CAS No.: 78765-15-8
• Molecular Formula: C₁₄H₂₀O₃
• Molecular Weight: 236.311
• Mol file: 78765-15-8.mol

Synonyms:

Chemical Property of 4-(3',4'-dimethoxyphenyl)-3-hexnone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3',4'-dimethoxyphenyl)-3-hexnone

There total 3 articles about 4-(3',4'-dimethoxyphenyl)-3-hexnone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3',4'-dimethoxyphenyl)-2-butanone (884-06-0) + ethyl iodide (75-03-6) → 4-(3',4'-dimethoxyphenyl)-3-hexnone (78765-15-8)

Guidance literature:

With sodium methylate;

DOI:10.1021/ja01598a062

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 4-(3',4'-dimethoxyphenyl)-3-hexnone (78765-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

2: p-TosOH / xylene / 5.5 h / Heating

3: tetra-n-butyl ammonium hydrogen sulfate, NaOH / CH₂Cl₂; H₂O / 16 h / Ambient temperature

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; water; xylene;

DOI:10.1016/S0039-128X(81)90304-4

Reference yield:

t-butyl 2-ethyl-2,3-epoxy-3-(3',4'-dimethoxyphenyl)-propanoate (78765-14-7) → 4-(3',4'-dimethoxyphenyl)-3-hexnone (78765-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TosOH / xylene / 5.5 h / Heating

2: tetra-n-butyl ammonium hydrogen sulfate, NaOH / CH₂Cl₂; H₂O / 16 h / Ambient temperature

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; In dichloromethane; water; xylene;

DOI:10.1016/S0039-128X(81)90304-4

upstream raw materials:

1-(3',4'-dimethoxyphenyl)-2-butanone

ethyl iodide

3,4-dimethoxy-benzaldehyde

t-butyl 2-ethyl-2,3-epoxy-3-(3',4'-dimethoxyphenyl)-propanoate

Downstream raw materials:

4-(3,4-dimethoxy-phenyl)-3-phenyl-hexan-3-ol

(+/-)-erythro-3-(3,4-dimethoxy-phenyl)-4-(4-fluoro-phenyl)-hexane

4-[(1RS,2SR)-1-ethyl-2-(4-fluoro-phenyl)-butyl]-pyrocatechol

(+/-)-erythro-3-(3,4-dimethoxy-phenyl)-4-phenyl-hexane

Refernces