Boc-L-β-cyanoalanine-3,4,5-trichlorophenyl ester

Base Information

• Chemical Name: Boc-L-β-cyanoalanine-3,4,5-trichlorophenyl ester
• CAS No.: 82215-22-3
• Molecular Formula: C₁₅H₁₅Cl₃N₂O₄
• Molecular Weight: 393.654
• Mol file: 82215-22-3.mol

Synonyms:

Chemical Property of Boc-L-β-cyanoalanine-3,4,5-trichlorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-L-β-cyanoalanine-3,4,5-trichlorophenyl ester

There total 2 articles about Boc-L-β-cyanoalanine-3,4,5-trichlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylasparagine (7536-55-2) → Boc-L-β-cyanoalanine-3,4,5-trichlorophenyl ester (82215-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / pyridine; dimethylformamide

2: dicyclohexylcarbodiimide / ethyl acetate; dimethylformamide / 36 h / Ambient temperature

With dicyclohexyl-carbodiimide; In pyridine; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)86771-4

Reference yield:

3,4,5-trichlorophenol (609-19-8) + (2S)-2-[(tert-butoxycarbonyl)amino]-3-cyanopropanoic acid (45159-34-0) → Boc-L-β-cyanoalanine-3,4,5-trichlorophenyl ester (82215-22-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide; for 36h; Ambient temperature;

DOI:10.1016/S0040-4039(00)86771-4

upstream raw materials:

3,4,5-trichlorophenol

(2S)-2-[(tert-butoxycarbonyl)amino]-3-cyanopropanoic acid

N-tert-butyloxycarbonylasparagine

Refernces