Neu5AcαOMe

Base Information

• Chemical Name: Neu5AcαOMe
• CAS No.: 6730-42-3
• Molecular Formula: C₁₂H₂₁NO₉
• Molecular Weight: 323.3
• Mol file: 6730-42-3.mol

Synonyms:

Chemical Property of Neu5AcαOMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Neu5AcαOMe

There total 9 articles about Neu5AcαOMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methanol (67-56-1) + 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (24967-27-9,79026-37-2,108675-60-1,108675-61-2,108675-62-3) → Neu5AcαOMe (6730-42-3,23755-35-3,50930-22-8,150718-07-3)

Guidance literature:

With Streptococcus pneumoniae sialidase (SpNanC); In water; at 37 ℃; for 28h; pH=7;

Reference yield: 8.4%

sialic acid (489-46-3,6813-81-6,14120-72-0,19342-33-7,21646-00-4,82349-00-6,99395-98-9,99395-99-0,99396-00-6,102734-10-1,140671-47-2,140850-42-6,140850-43-7,140850-44-8,145375-13-9) → Neu5AcαOMe (6730-42-3,23755-35-3,50930-22-8,150718-07-3)

Guidance literature:

DOI:10.1016/S0008-6215(00)88049-0

Reference yield:

3'-sialyllactose (18409-13-7,64839-32-3,64839-33-4,102778-91-6,102778-92-7) → Neu5AcαOMe (6730-42-3,23755-35-3,50930-22-8,150718-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Streptococcus pneumoniae sialidase (SpNanC) / Enzymatic reaction

2: Streptococcus pneumoniae sialidase (SpNanC) / water / 28 h / 37 °C / pH 7

With Streptococcus pneumoniae sialidase (SpNanC); In water;

upstream raw materials:

sialic acid

methyl (methyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate

3'-sialyllactose

methanol

Refernces

• 1、 -. "SIALIDASE INHIBITORS AND PREPARATION THEREOF". . . Retrieved 2018/11/22.
• 2、 Sparks, Michelle A.,Williams, Kevin W.,Lukacs, Christine,Schrell, Andreas,Priebe, Gregory,Spaltenstein, Andreas,Whitesides, George M.. "Synthesis of potential inhibitors of hemagglutination by influenza virus: Chemoenzymic preparation of N-5 analogs of N-acetylneuraminic acid". . p. 1 - 12. Retrieved 2007/10/02.