7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine

Base Information

• Chemical Name: 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine
• CAS No.: 84201-40-1
• Molecular Formula: C₁₀H₁₂N₂S₂
• Molecular Weight: 224.351
• Mol file: 84201-40-1.mol

Synonyms:7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine

Chemical Property of 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine

Chemical Property:

• Melting Point: 66 °C
• PKA: 1.12±0.30(Predicted)
• PSA: 67.90000
• Density: 1.25g/cm³
• LogP: 3.08650
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL, clear

Purity/Quality:

99%+ ^*data from raw suppliers

Oltipraz metabolite M2 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine

There total 9 articles about 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

7-methyl-pyrrolo[1,2-a]pyrazine-6,8-dithiol + methyl iodide (74-88-4) + Oltipraz (64224-21-1) → 7-methyl-6,8-bis(methylthio)pyrrolo<1,2-a>pyrazine (84201-40-1)

Guidance literature:

Oltipraz; With L-Cysteine; sodium ethanolate; In ethanol; at 35 ℃; for 2h;

7-methyl-pyrrolo[1,2-a]pyrazine-6,8-dithiol; methyl iodide; In ethanol; at 35 ℃;

Reference yield: 75.0%

methyl iodide (74-88-4) + Oltipraz (64224-21-1) → 7-methyl-6,8-bis(methylthio)pyrrolo<1,2-a>pyrazine (84201-40-1)

Guidance literature:

With tetrabutylammonium perchlorate; In acetonitrile; -1050 mV S_.C_.E_.;

DOI:10.1016/S0040-4020(01)87440-8

Reference yield: 30.0%

8-Mercapto-7-methyl-2H-pyrrolo[1,2-a]pyrazine-6-thione (101623-05-6) + methyl iodide (74-88-4) → 7-methyl-6,8-bis(methylthio)pyrrolo<1,2-a>pyrazine (84201-40-1) + 7-methyl-6 (or 8-)-methylthio-pyrrolo<1,2-a>pyrazine disulphide (87578-53-8)

Guidance literature:

With sodium ethanolate; In ethyl acetate;

DOI:10.1016/S0040-4020(01)87440-8

upstream raw materials:

8-Mercapto-7-methyl-2H-pyrrolo[1,2-a]pyrazine-6-thione

methyl iodide

sodium thioethylate

Oltipraz

Refernces

• 1、 Prochaska, Hans J.,Bornmann, William G.,Baron, Penny,Polsky, Bruce. "Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz". . p. 15 - 20. Retrieved 2007/10/03.
• 2、 Largeron, M.,Martens, T.,Fleury, M. B.. "REACTIVITY OF SUBSTITUTED 1,2-DITHIOLE-3-THIONES WITH SODIUM ETHANETHIOLATE: A CONVENIENT ROUTE TO A NOVEL HETEROCYCLE.". . p. 3421 - 3428. Retrieved 2007/10/02.