2-HYDROXY-PENT-4-ENOIC ACID

Base Information

• Chemical Name: 2-HYDROXY-PENT-4-ENOIC ACID
• CAS No.: 67951-43-3
• Molecular Formula: C5H8 O3
• Molecular Weight: 116.117
• Mol file: 67951-43-3.mol

Synonyms:4-Pentenoic acid,2-hydroxy;2-hydroxy-pent-4-enoic acid;2-hydroxy-4-pentenoic acid;2-Hydroxy-pent-4-ensaeure;3-Vinyllactic acid;2-allylglycolic acid;

Chemical Property of 2-HYDROXY-PENT-4-ENOIC ACID

Chemical Property:

• Vapor Pressure: 0.00101mmHg at 25°C
• Melting Point: 37℃ (ethyl ether ligroine )
• Refractive Index: 1.4117 (589.3 nm 20℃)
• Boiling Point: 268.8°C at 760 mmHg
• PKA: 3.79±0.11(Predicted)
• Flash Point: 130.6°C
• PSA: 57.53000
• Density: 1.176g/cm³
• LogP: 0.00800

Purity/Quality:

99%min ^*data from raw suppliers

2-HYDROXY-PENT-4-ENOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-PENT-4-ENOIC ACID

There total 11 articles about 2-HYDROXY-PENT-4-ENOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

allyl bromide (106-95-6) + 2,2-dihydroxyacetic acid (563-96-2) → 2-hydroxypent-4-enoic acid (67951-43-3)

Guidance literature:

With bismuth(III) chloride; zinc;

DOI:10.1021/jo010885c

Reference yield: 93.0%

allyltributylstanane (24850-33-7) + Glyoxilic acid (298-12-4) → 2-hydroxypent-4-enoic acid (67951-43-3)

Guidance literature:

With indium(III) chloride; hexylmethylimidazolium chloride; for 8h;

DOI:10.1055/s-2004-815433

Reference yield: 93.0%

allyl bromide (106-95-6) + Glyoxilic acid (298-12-4) → 2-hydroxypent-4-enoic acid (67951-43-3)

Guidance literature:

With bismuth(III) chloride; zinc; In tetrahydrofuran; at 20 ℃;

DOI:10.1246/bcsj.70.2265

upstream raw materials:

Ethyl 2-chloro-4-pentenoate

2-bromopent-4-enoic acid ethyl ester

glycolic acid allyl ester

1-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-but-3-en-1-ol

Downstream raw materials:

5-allyl-2,2-dimethyl-1,3-dioxolan-4-one

2-(4-methoxybenzyloxy)pent-4-enoic acid

2-(4-Chlor-benzoyloxy)-4-pentensaeure

1,3-butadiene-1-carboxylic acid

Refernces

• 1、 Isono, Takuya,Kaizawa, Noya,Ree, Brian J.,Satoh, Toshifumi,Tajima, Kenji,Watanabe, Kodai,Yamamoto, Takuya. "One-Shot Intrablock Cross-Linking of Linear Diblock Copolymer to Realize Janus-Shaped Single-Chain Nanoparticles". . p. 18122 - 18128. Retrieved 2021.
• 2、 Ishoey, Mette,Petersen, Rico G.,Petersen, Michael ?.,Wu, Peng,Clausen, Mads H.,Nielsen, Thomas E.. "Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions". supporting information. p. 9410 - 9413. Retrieved 2017/08/29.