N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide

Base Information

• Chemical Name: N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide
• CAS No.: 1428327-31-4
• Molecular Formula: C₂₈H₃₂N₄O₂S
• Molecular Weight: 488.654
• Mol file: 1428327-31-4.mol

Synonyms:

Chemical Property of N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

JNJ 47965567 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux, which is reduced by JNJ-47965567 in 1321N1 cells transfected with recombinant P2X7 human, macaque, dog, rat, or mouse protein with pIC50s of 8.3, 8.6, 8.5, 7.2, or 7.5, respectively. JNJ-47965567 suppresses neonatal hypoxia-induced seizures in mice and has some anticonvulsant properties in rats. It also reduces spontaneous seizures in epileptic mice even after treatment is stopped.
• Uses: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-3-pyridinecarboxamide is a potent and selective human P2X7 antagonist.

Technology Process of N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide

There total 5 articles about N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methanamine (1157013-41-6) + 2-(phenylthio)nicotinoyl chloride (165249-92-3) → N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide (1428327-31-4)

Guidance literature:

In dichloromethane; at 20 - 38 ℃; for 2.75h; Inert atmosphere;

DOI:10.1021/ml400040v

Reference yield:

4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-carbonitrile (1428327-30-3) → N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide (1428327-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 2.75 h / 20 - 38 °C / Inert atmosphere

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ml400040v

Reference yield:

4-phenyl-1-piperazine (92-54-6) → N-[[4-(4-phenyl-piperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl]-2-(phenylthio)nicotinamide (1428327-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1: water / 20 °C / pH 3 / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: dichloromethane / 2.75 h / 20 - 38 °C / Inert atmosphere

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ml400040v

upstream raw materials:

2-(phenylthio)nicotinic acid

4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-carbonitrile

4-phenyl-1-piperazine

Tetrahydro-4H-pyran-4-one

Refernces