3-Chloro-4-fluorobenzenesulfonyl chloride

Base Information

• Chemical Name: 3-Chloro-4-fluorobenzenesulfonyl chloride
• CAS No.: 91170-93-3
• Molecular Formula: C6H3Cl2FO2S
• Molecular Weight: 229.059
• Hs Code.: 29049090
• Mol file: 91170-93-3.mol

Synonyms:3-Chloro-4-fluorobenzene-1-sulfonylchloride;3-Chloro-4-fluorobenzensulfonylchloride;3-Chloro-4-fluorophenylsulfonyl chloride;

Chemical Property of 3-Chloro-4-fluorobenzenesulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.00126mmHg at 25°C
• Refractive Index: n20/D 1.5220(lit.)
• Boiling Point: 308.1 °C at 760 mmHg
• Flash Point: 140.2 °C
• PSA: 42.52000
• Density: 1.61 g/cm³
• LogP: 3.48740
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-fluorobenzenesulfonyl Chloride >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-Chloro-4-fluorobenzenesulfonyl chloride

There total 2 articles about 3-Chloro-4-fluorobenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-chloro-4-fluoro-benzenethiol (60811-23-6) → 4-fluoro-3-chlorobenzenesulfonyl chloride (91170-93-3)

Guidance literature:

With Oxone; potassium chloride; In water; at 20 ℃; for 0.25h;

DOI:10.1039/c4gc00246f

Reference yield:

→ 4-fluoro-3-chlorobenzenesulfonyl chloride (91170-93-3)

Guidance literature:

Reference yield: 98.0%

p-aminomethylbenzoic acid (56-91-7) + 4-fluoro-3-chlorobenzenesulfonyl chloride (91170-93-3) → 4-{[(3-chloro-4-fluorophenyl)sulfonamido]methyl}benzoic acid (690646-06-1)

Guidance literature:

With borax; In water; at 20 ℃; for 4h; Sonication;

DOI:10.1016/j.ejmech.2017.02.018

upstream raw materials:

3-chloro-4-fluoro-benzenethiol

Downstream raw materials:

(S)-1-(3-Chloro-4-fluoro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid

1-(3-chloro-4-fluoro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid

3-chloro-4-fluorobenzenesulfonamide

3-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide

Refernces

• 1、 -. "Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists". . . Retrieved 2008/06/13.