4'-Chloroflavone

Base Information

• Chemical Name: 4'-Chloroflavone
• CAS No.: 10420-75-4
• Molecular Formula: C15H9 Cl O2
• Molecular Weight: 256.688
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID90146345
• Nikkaji Number: J435.645D
• Wikidata: Q27452470
• Pharos Ligand ID: NXFYWVY2SJPU
• Metabolomics Workbench ID: 74468
• ChEMBL ID: CHEMBL16783
• Mol file: 10420-75-4.mol

Synonyms:4'-chloroflavone

Chemical Property of 4'-Chloroflavone

Chemical Property:

• Boiling Point: 391°Cat760mmHg
• Flash Point: 163.7°C
• PSA: 30.21000
• Density: 1.342g/cm³
• LogP: 4.11340
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 256.0291072
• Heavy Atom Count: 18
• Complexity: 356

Purity/Quality:

98%,99%, ^*data from raw suppliers

4'-CHLOROFLAVONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)C=C(O2)C3=CC=C(C=C3)Cl

Technology Process of 4'-Chloroflavone

There total 71 articles about 4'-Chloroflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-acetoxyphenyl)-3-(4-chlorophenyl)-2-propyn-1-one → 4'-chloroflavone (10420-75-4)

Guidance literature:

With piperazine; In acetonitrile; at 20 ℃; for 3h; Schlenk technique;

Reference yield: 98.0%

4'-chloroflavanone (93514-36-4,126784-71-2,3034-10-4) → 4'-chloroflavone (10420-75-4)

Guidance literature:

With thallium(III) acetate; In acetic acid; for 3h; Heating;

DOI:10.1016/S0040-4039(00)88832-2

Reference yield: 97.0%

4-chloro-2'-hydroxychalcone (3033-96-3) → 4'-chloroflavone (10420-75-4)

Guidance literature:

With Iodine monochloride; dimethyl sulfoxide; at 50 ℃; for 0.5h; Sonication; Green chemistry;

DOI:10.1016/j.ultsonch.2016.02.018

upstream raw materials:

1-(4-chloro-phenyl)-3-(2-hydroxy-phenyl)-propane-1,3-dione

methanol

4-chloro-2'-hydroxychalcone

(E)-2'-hydroxy-4-chlorochalcone

Downstream raw materials:

7a-(4-Chloro-phenyl)-1a,7a-dihydro-1H-7-oxa-cyclopropa[b]naphthalen-2-one

1a,7a-Dihydro-1a-(4-chlorophenyl)-7H-oxireno<1>benzopyran-7-one

4'-chloro-4-thionoflavone

2-(4-Chloro-phenyl)-chromen-4-one oxime

Refernces

• 1、 Vimal, Manorama,Pathak, Uma,Mathur, Sweta,Pandey, Lokesh Kumar,Suryanarayana. "Silica-PCL5: An efficient and reusable catalyst for cyclodehydration of 1, 3-diketones to flavones". . p. 151 - 154. Retrieved 2010.
• 2、 Yatabe, Takafumi,Jin, Xiongjie,Yamaguchi, Kazuya,Mizuno, Noritaka. "Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One-Pot Synthesis of Flavones". . p. 13302 - 13306. Retrieved 2015.
• 3、 Banerjee, Dipanwita,Kayal, Utpal,Maiti, Gourhari. "An efficient oxidative conversion of 2-aryl-2H-chromenes to the corresponding flavones by tert-butylhydroperoxide and copper bromide". . p. 1667 - 1671. Retrieved 2016.
• 4、 Hoshino, Yukio,Oohinata, Toshinori,Takeno, Noboru. "The Direct Preparation of Flavones from 2'-Hydroxychalcones Using Disulfides". . p. 2351 - 2352. Retrieved 1986.
• 5、 Vimal, Manorama,Pathak, Uma,Halve, Anand Kumar. "Water-mediated phosphorylative cyclodehydrogenation: An efficient preparation of flavones and flavanones". . p. 2805 - 2814. Retrieved 2019.
• 6、 Alsantali, Reem?I.,Mughal, Ehsan?Ullah,Naeem, Nafeesa,Alsharif, Meshari?A.,Sadiq, Amina,Ali, Anser,Jassas, Rabab.?S.,Javed, Qamar,Javid, Asif,Sumrra, Sajjad Hussain,Alsimaree, Abdulrahman?A.,Zafar, Muhammad?Naveed,Asghar, Basim?H.,Altass, Hatem?M.,Moussa, Ziad,Ahmed, Saleh?A.. "Flavone-based hydrazones as new tyrosinase inhibitors: Synthetic imines with emerging biological potential, SAR, molecular docking and drug-likeness studies". . . Retrieved 2021/11/30.
• 7、 Ahmed, Ishtiaq,Ahmed, Safeer,Ahmed, Saleh A.,Alsantali, Reem I.,Alsharif, Meshari A.,Altaf, Ataf Ali,Altass, Hatem M.,Jassas, Rabab. S.,Kausar, Samia,Mughal, Ehsan Ullah,Mumtaz, Amara,Naeem, Nafeesa,Obaid, Rami J.,Sadiq, Amina,Zafar, Muhammad Naveed. "Experimental and theoretical insights into the photophysical and electrochemical properties of flavone-based hydrazones". . . Retrieved 2021/07/06.