Lincomycin 2,7-diacetate

Base Information

• Chemical Name: Lincomycin 2,7-diacetate
• CAS No.: 2132-62-9
• Molecular Formula: C16H14 O2
• Molecular Weight: 238.286
• Hs Code.: 2909309090
• Mol file: 2132-62-9.mol

Synonyms:Acetylene,bis(p-methoxyphenyl)- (6CI,7CI,8CI); 1,2-(4-Methoxyphenyl)acetylene;1,2-Bis(4-methoxyphenyl)acetylene; 1,2-Bis(4-methoxyphenyl)ethyne;1,2-Bis(p-anisyl)acetylene; 1,2-Di(4-methoxyphenyl)acetylene;4,4'-Dimethoxydiphenylacetylene; 4,4'-Dimethoxytolan;Bis(4-methoxyphenyl)acetylene; Bis(p-methoxyphenyl)acetylene;Di(p-methoxyphenyl)acetylene; Di-4-methoxyphenylacetylene;Di-p-anisylacetylene; p,p'-Dimethoxydiphenylacetylene

Chemical Property of Lincomycin 2,7-diacetate

Chemical Property:

• Vapor Pressure: 7.71E-20mmHg at 25°C
• Melting Point: 143
• Boiling Point: 653.4°C at 760 mmHg
• Flash Point: 348.9°C
• PSA: 18.46000
• Density: 1.26g/cm³
• LogP: 3.10360
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1,2-Bis(4-methoxyphenyl)ethyne 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Chemical Synthesis Intermediate

Technology Process of Lincomycin 2,7-diacetate

There total 159 articles about Lincomycin 2,7-diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromo-4-methoxy-benzene (104-92-7) + 4-methoxyphenylacetylen (768-60-5) → 4,4'-dimethoxydiphenylacetylene (2132-62-9)

Guidance literature:

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1002/anie.201409733

Reference yield: 99.0%

1-bromo-2-(4-methoxyphenyl)acetylene (33675-41-1) + 4-methoxyphenylboronic acid (5720-07-0) → 4,4'-dimethoxydiphenylacetylene (2132-62-9)

Guidance literature:

With copper(l) iodide; 8-quinolinol; sodium phosphate; In ethanol; at 80 ℃; for 24h;

DOI:10.1016/j.tet.2011.05.031

Reference yield: 98.0%

para-iodoanisole (696-62-8) + 4-methoxyphenylacetylen (768-60-5) → 4,4'-dimethoxydiphenylacetylene (2132-62-9)

Guidance literature:

With copper(l) iodide; 2,2'-diamino-6,6'-dimethylbiphenyl; sodium hydroxide; In dimethyl sulfoxide; at 115 ℃; for 24h; Inert atmosphere;

DOI:10.1246/bcsj.20100327

upstream raw materials:

2-chloro-1,1-bis-(4-methoxy-phenyl)-ethene

sodium ethanolate

2,2-bis-(p-methoxyphenyl)-1-bromoethylene

1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene

Downstream raw materials:

1-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethanone

1,4-di(4-methoxyphenyl)ethanone

1,2-bis(4-methoxyphenyl)ethane

cis-4,4'-dimethoxystilbene

Refernces

• 1、 Thompson, Richard R.,Rotella, Madeline E.,Zhou, Xin,Fronczek, Frank R.,Gutierrez, Osvaldo,Lee, Semin. "Impact of Ligands and Metals on the Formation of Metallacyclic Intermediates and a Nontraditional Mechanism for Group VI Alkyne Metathesis Catalysts". . p. 9026 - 9039. Retrieved 2021.
• 2、 Copéret, Christophe,Fürstner, Alois,Gordon, Christopher P.,Hillenbrand, Julius,Leutzsch, Markus. "183W NMR Spectroscopy Guides the Search for Tungsten Alkylidyne Catalysts for Alkyne Metathesis". . p. 21758 - 21768. Retrieved 2020.
• 3、 Chabre, Yoann M.,Brisebois, Patrick P.,Abbassi, Leila,Kerr, Sheena C.,Fahy, John V.,Marcotte, Isabelle,Roy, Rene. "Hexaphenylbenzene as a rigid template for the straightforward syntheses of "star-shaped" glycodendrimers". . p. 724 - 727. Retrieved 2011.
• 4、 Artem'ev, Alexander V.,Malysheva, Svetlana F.,Gusarova, Nina K.,Belogorlova, Nataliya A.,Sukhov, Boris G.,Sutyrina, Anastasiya O.,Matveeva, Elena A.,Vasilevsky, Sergey F.,Govdi, Anastasiya I.,Gatilov, Yuriy V.,Albanov, Alexander I.,Trofimov, Boris A.. "Reaction of elemental phosphorus with α-methylstyrenes: One-pot synthesis of secondary and tertiary phosphines, prospective bulky ligands for Pd(II) catalysts". . p. 443 - 450. Retrieved 2016.
• 5、 Shintani, Ryo,Takagi, Chihiro,Ito, Tomoaki,Naito, Masanobu,Nozaki, Kyoko. "Rhodium-catalyzed asymmetric synthesis of silicon-stereogenic dibenzosiloles by enantioselective[2+2+2] cycloaddition". . p. 1616 - 1620. Retrieved 2015.
• 6、 Zhang, Yu-Yang,Li, Han,Jiang, Xiaoding,Subba Reddy, Chitreddy V,Liang, Hao,Zhang, Yaqi,Cao, Rihui,Sun, Raymond Wai-Yin,Tse, Man Kin,Qiu, Liqin. "Nickel-Catalyzed Decarbonylative Cycloaddition of Benzofuran-2,3-diones with Alkynes to Flavones". supporting information. p. 525 - 530. Retrieved 2021/12/22.
• 7、 Prusty, Namrata,Banjare, Shyam Kumar,Mohanty, Smruti Ranjan,Nanda, Tanmayee,Yadav, Komal,Ravikumar, Ponneri C.. "Synthesis and Photophysical Study of Heteropolycyclic and Carbazole Motif: Nickel-Catalyzed Chelate-Assisted Cascade C-H Activations/Annulations". supporting information. p. 9041 - 9046. Retrieved 2021/11/30.