ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate

Base Information

• Chemical Name: ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate
• CAS No.: 83537-31-9
• Molecular Formula: C₁₈H₁₅ClO₅
• Molecular Weight: 346.767
• Mol file: 83537-31-9.mol

Synonyms:

Chemical Property of ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate

There total 4 articles about ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.6%

glyoxylic acid ethyl ester (924-44-7) + 2-chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone (13221-80-2) → ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate (83537-31-9,94402-66-1)

Guidance literature:

With sodium ethanolate; In ethanol; for 2h; Ambient temperature;

DOI:10.1248/cpb.32.3066

Reference yield:

bromobenzene (108-86-1,52753-63-6) → ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate (83537-31-9,94402-66-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / CuCl₂ / pyridine / 10 h / Heating

2: 70 percent / AlCl₃ / CS₂

3: 61.6 percent / NaOEt / ethanol / 2 h / Ambient temperature

With aluminium trichloride; sodium ethanolate; copper dichloride; In pyridine; carbon disulfide; ethanol;

DOI:10.1248/cpb.32.3066

Reference yield:

4-chlorodiphenyl ether (7005-72-3) → ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate (83537-31-9,94402-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / AlCl₃ / CS₂

2: 61.6 percent / NaOEt / ethanol / 2 h / Ambient temperature

With aluminium trichloride; sodium ethanolate; In carbon disulfide; ethanol;

DOI:10.1248/cpb.32.3066

upstream raw materials:

glyoxylic acid ethyl ester

2-chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone

bromobenzene

4-chlorodiphenyl ether

Downstream raw materials:

cis-3-<4-(4-chlorophenoxy)benzoyl>glycidic acid

trans-3-<4-(4-chlorophenoxy)benzoyl>glycidic acid

Refernces