6,8-dibromocatechin

Base Information

• Chemical Name: 6,8-dibromocatechin
• CAS No.: 88038-00-0
• Molecular Formula: C₁₅H₁₂Br₂O₆
• Molecular Weight: 448.065
• Mol file: 88038-00-0.mol

Synonyms:

Chemical Property of 6,8-dibromocatechin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,8-dibromocatechin

There total 2 articles about 6,8-dibromocatechin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

epicatechin-(4β->6)-epicatechin-(2β->O->7, 4β->8)-epicatechin-(4β->8)-epicatechin (88038-15-7,100163-70-0) → 6,8-dibromo-(-)-epicatechin (88038-00-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 120 mg / acetic acid, phenylmethanethiol / ethanol

2: 85 mg / phenylmethanethiol, acetic acid / ethanol / 4 h / Heating

3: pyridinium hydrobromide perbromide / acetonitrile / 0 °C

With pyridinium hydrobromide perbromide; acetic acid; phenylmethanethiol; In ethanol; acetonitrile;

Reference yield:

cinnamtannin B-1 (88082-60-4) → 6,8-dibromo-(-)-epicatechin (88038-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 mg / phenylmethanethiol, acetic acid / ethanol / 4 h / Heating

2: pyridinium hydrobromide perbromide / acetonitrile / 0 °C

With pyridinium hydrobromide perbromide; acetic acid; phenylmethanethiol; In ethanol; acetonitrile;

Reference yield:

6,8-dibromocatechin (88038-00-0,88488-98-6,105815-57-4) → 6-bromocatechin (88038-02-2,88488-99-7,105815-61-0) + catechin (154-23-4,490-46-0,7295-85-4,17334-50-8,18829-70-4,35323-91-2,72690-97-2,13392-26-2)

Guidance literature:

With sodium sulfite; In [D₃]acetonitrile; water-d2; for 2.26667h; Product distribution; study of the debromination reaction, mechanism is dicussed;

upstream raw materials:

cinnamtannin B-1

epicatechin-(4β->6)-epicatechin-(2β->O->7, 4β->8)-epicatechin-(4β->8)-epicatechin

Downstream raw materials:

6,8-dibromo-5,7,3',4'-tetramethoxyepicatechin

6-bromocatechin

catechin

6,8-dibromo-3-O-acetyl-3',4',5,7-tetra-O-methyl-(-)-epicatechin

Refernces