Technology Process of tris[(2,3-dimethyl-5-benzyloxy-6-carboxamido-4-pyrimidinone)ethyl]amine
There total 7 articles about tris[(2,3-dimethyl-5-benzyloxy-6-carboxamido-4-pyrimidinone)ethyl]amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C
2.2: 8 h / 65 °C
3.1: sodium hypochlorite; sodium hydrogencarbonate; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0.33 h / 0 - 4 °C
3.2: pH 10
3.3: pH 2
4.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h
With
hydrogenchloride; sodium hypochlorite; sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; sodium bromide;
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C
1.2: 8 h / 65 °C
2.1: sodium hypochlorite; sodium hydrogencarbonate; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0.33 h / 0 - 4 °C
2.2: pH 10
2.3: pH 2
3.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h
With
sodium hypochlorite; sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; sodium bromide;
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h
1.2: 18 h
2.1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C
3.2: 8 h / 65 °C
4.1: sodium hypochlorite; sodium hydrogencarbonate; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0.33 h / 0 - 4 °C
4.2: pH 10
4.3: pH 2
5.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h
With
hydrogenchloride; sodium hypochlorite; sodium hydride; sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; sodium bromide;
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;