Technology Process of 2-[3-(2-benzo[d] isoxazol-3-ylimidazo[1,2-a]pyridin-6-yl)phenyl]propan-2-ol
There total 7 articles about 2-[3-(2-benzo[d] isoxazol-3-ylimidazo[1,2-a]pyridin-6-yl)phenyl]propan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ethanol; sodium hydrogencarbonate;
for 20h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 21 h / 0 - 20 °C
2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere
3: ethanol; sodium hydrogencarbonate / 20 h / Reflux
With
ethanol; sodium hydrogencarbonate; caesium carbonate; triethylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran; diethyl ether; dibutyl ether / 1 h / 0 °C / Inert atmosphere
1.2: 0 °C
2.1: triethylamine / dichloromethane / 21 h / 0 - 20 °C
3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere
4.1: ethanol; sodium hydrogencarbonate / 20 h / Reflux
With
ethanol; sodium hydrogencarbonate; caesium carbonate; triethylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; dibutyl ether; water;