10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline

Base Information

• Chemical Name: 10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline
• CAS No.: 61013-20-5
• Molecular Formula: C₁₉H₁₇NO₂
• Molecular Weight: 291.349
• Mol file: 61013-20-5.mol

Synonyms:

Chemical Property of 10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline

There total 3 articles about 10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline (38291-33-7) → 10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline (61013-20-5) + 10,11-dimethoxy-6-methyl-5,6-dihydro-4H-dibenzo[de,g]quinoline (18605-43-1)

Guidance literature:

With palladium 10% on activated carbon; In acetonitrile; Overall yield = 10.6 g; Reflux;

Reference yield:

Apocodeine (641-36-1) → 10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline (61013-20-5) + 10,11-dimethoxy-6-methyl-5,6-dihydro-4H-dibenzo[de,g]quinoline (18605-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h

1.2: 0.5 h

2.1: palladium 10% on activated carbon / acetonitrile / Reflux

With palladium 10% on activated carbon; sodium hydride; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

codeine (76-57-3) → 10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline (61013-20-5) + 10,11-dimethoxy-6-methyl-5,6-dihydro-4H-dibenzo[de,g]quinoline (18605-43-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanesulfonic acid / 1 h

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h

2.2: 0.5 h

3.1: palladium 10% on activated carbon / acetonitrile / Reflux

With methanesulfonic acid; palladium 10% on activated carbon; sodium hydride; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

Apocodeine

(R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

codeine

Refernces

• 1、 -. "PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES". . . Retrieved 2021/02/12.