Kalydeco benzenesulfonate

Base Information

• Chemical Name: Kalydeco benzenesulfonate
• CAS No.: 1134822-09-5
• Molecular Formula: C₆H₆O₃S*C₂₄H₂₈N₂O₃
• Molecular Weight: 550.676
• Mol file: 1134822-09-5.mol

Synonyms:

Chemical Property of Kalydeco benzenesulfonate

Chemical Property:

• Solubility.: ≥55.1 mg/mL in DMSO; insoluble in H2O; ≥13.86 mg/mL in EtOH with gentle warming

Purity/Quality:

99%+, ^*data from raw suppliers

IvacaftorBenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ivacaftor Benzenesulfonate is a salt of Ivacaftor, a novel agent for the treatment of cystic fibrosis.

Technology Process of Kalydeco benzenesulfonate

There total 1 articles about Kalydeco benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ivacaftor (873054-44-5,1174930-71-2) + benzenesulfonic acid (98-11-3) → N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide.besylate (1134822-09-5)

Guidance literature:

In Isopropyl acetate; at 20 - 32.5 ℃; for 23 - 24h; Product distribution / selectivity;

upstream raw materials:

ivacaftor

benzenesulfonic acid

Refernces