Technology Process of C19H18N2O2S
There total 5 articles about C19H18N2O2S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
DOI:10.1016/j.bmcl.2011.06.128
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0 - 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 85 °C
3: water; lithium hydroxide / methanol / Reflux
4: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
With
dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
2: Suzuki cross coupling reaction;
DOI:10.1016/j.bmcl.2011.06.128
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; lithium hydroxide / methanol / Reflux
2: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
With
dmap; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.06.128