ethyl 3'-nitrobiphenyl-2-carboxylate

Base Information

• Chemical Name: ethyl 3'-nitrobiphenyl-2-carboxylate
• CAS No.: 1195761-05-7
• Molecular Formula: C₁₅H₁₃NO₄
• Molecular Weight: 271.273
• Mol file: 1195761-05-7.mol

Synonyms:

Chemical Property of ethyl 3'-nitrobiphenyl-2-carboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Ethyl3'-nitro-[1,1'-biphenyl]-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3'-nitrobiphenyl-2-carboxylate

There total 3 articles about ethyl 3'-nitrobiphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

potassium m-nitrobenzoate (18312-48-6) + 2-trifluoromethylsulfonyloxybenzoic acid ethyl ester (179538-97-7) → ethyl 3'-nitrobiphenyl-2-carboxylate (1195761-05-7)

Guidance literature:

With tol-BINAP; copper(I) oxide; 1,10-Phenanthroline; palladium(II) bromide; In 1-methyl-pyrrolidin-2-one; at 50 - 190 ℃; Microwave irradiation; Inert atmosphere;

DOI:10.1002/chem.200900892

Reference yield:

ethyl 2-iodobenzoate (1829-28-3) + m-nitrobenzene boronic acid (13331-27-6) → ethyl 3'-nitrobiphenyl-2-carboxylate (1195761-05-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.3987/COM-20-14292

Reference yield:

benzoic acid ethyl ester (93-89-0,99341-95-4) + nitrobenzene (98-95-3,26969-40-4) → ethyl 3'-nitrobiphenyl-2-carboxylate (1195761-05-7) + 4'-nitro-biphenyl-2-carboxylic acid ethyl ester

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; at 90 ℃; for 40h;

DOI:10.1021/om300114e

upstream raw materials:

potassium m-nitrobenzoate

2-trifluoromethylsulfonyloxybenzoic acid ethyl ester

benzoic acid ethyl ester

nitrobenzene

Downstream raw materials:

3'-nitro-[1,1'-biphenyl]-2-carboxylic acid

6-nitro-3,4-benzocoumarin

Refernces

• 1、 Zhou, Lihong,Lu, Wenjun. "Palladium(II)-catalyzed coupling of electron-deficient arenes via C-H activation". scheme or table. p. 2124 - 2127. Retrieved 2012/06/01.