Technology Process of (4E,13E)-(3aS,9S)-9-Methyl-1,2,3,3a,6,9,10,11,12,14a-decahydro-8-oxa-cyclopentacyclotridecen-7-one
There total 6 articles about (4E,13E)-(3aS,9S)-9-Methyl-1,2,3,3a,6,9,10,11,12,14a-decahydro-8-oxa-cyclopentacyclotridecen-7-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
Methanesulfonic acid (4E,13E)-(3aS,9S)-9-methyl-7-oxo-2,3,3a,6,7,9,10,11,12,14a-decahydro-1H-8-oxa-cyclopentacyclotridecen-2-yl ester
-
-
95192-04-4
(4E,13E)-(3aS,9S)-9-Methyl-1,2,3,3a,6,9,10,11,12,14a-decahydro-8-oxa-cyclopentacyclotridecen-7-one
- Guidance literature:
-
With
sodium iodide; zinc;
In
various solvent(s);
at 65 ℃;
for 1.5h;
Yield given;
DOI:10.1021/ja00294a045
-
-
95192-04-4
(4E,13E)-(3aS,9S)-9-Methyl-1,2,3,3a,6,9,10,11,12,14a-decahydro-8-oxa-cyclopentacyclotridecen-7-one
- Guidance literature:
-
Multi-step reaction with 6 steps
1: PCC / CH2Cl2 / Ambient temperature
2: CH2Cl2 / 3 h / Ambient temperature
3: 31 percent / (n-Bu)3SnH, AIBN, Pd(PPH3)4 / toluene / 0.17 h / 75 °C
4: NaBH4 / propan-2-ol / 1.5 h / Ambient temperature
5: pyridine / 2 h / -15 °C
6: NaI, Zn / various solvent(s) / 1.5 h / 65 °C
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; pyridinium chlorochromate; sodium iodide; zinc;
In
pyridine; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1021/ja00294a045
-
-
95216-32-3
(4E,13E)-(3aS,9S)-9-Methyl-1,3a,6,9,10,11,12,14a-octahydro-3H-8-oxa-cyclopentacyclotridecene-2,7-dione
-
-
95192-04-4
(4E,13E)-(3aS,9S)-9-Methyl-1,2,3,3a,6,9,10,11,12,14a-decahydro-8-oxa-cyclopentacyclotridecen-7-one
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaBH4 / propan-2-ol / 1.5 h / Ambient temperature
2: pyridine / 2 h / -15 °C
3: NaI, Zn / various solvent(s) / 1.5 h / 65 °C
With
sodium tetrahydroborate; sodium iodide; zinc;
In
pyridine; isopropyl alcohol;
DOI:10.1021/ja00294a045