2,N-DIPHENYLACETAMIDE

Base Information

• Chemical Name: 2,N-DIPHENYLACETAMIDE
• CAS No.: 621-06-7
• Molecular Formula: C14H13 N O
• Molecular Weight: 211.263
• Hs Code.: 2924299090
• Mol file: 621-06-7.mol

Synonyms:Acetanilide,2-phenyl- (6CI,7CI,8CI); 2-Phenylacetanilide; Glycomide; N,2-Diphenylacetamide;N-(Phenylacetyl)aniline; N-Phenylbenzeneacetamide; NSC 15072;Phenylacetanilide; Phenylacetic acid anilide; a-Phenylacetanilide; a-Toluanilide; w-Phenylacetanilide

Chemical Property of 2,N-DIPHENYLACETAMIDE

Chemical Property:

• Vapor Pressure: 2.37E-07mmHg at 25°C
• Melting Point: 118 °C
• Boiling Point: 422.7°C at 760 mmHg
• PKA: 15.00±0.70(Predicted)
• Flash Point: 253.4°C
• PSA: 29.10000
• Density: 1.153g/cm³
• LogP: 2.94080
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N,2-Diphenylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,N-DIPHENYLACETAMIDE

There total 151 articles about 2,N-DIPHENYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-4-oxo-4-phenylbut-2-en-2-yl 2-phenylacetate + aniline (62-53-3) → 2,N-diphenylacetamide (621-06-7) + 1-phenylbutan-1,3-dione (93-91-4)

Guidance literature:

With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/jacs.1c04614

Reference yield: 89.0%

diphenyl acetylene (501-65-5) → 2,N-diphenylacetamide (621-06-7)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; trimethylsilylazide; water; silver carbonate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 60 ℃; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201303376

Reference yield: 87.0%

Benzeneacetamide (103-81-1) + aniline (62-53-3) → 2,N-diphenylacetamide (621-06-7)

Guidance literature:

With sulfated tungstate; In toluene; for 12h; Reflux; Green chemistry;

DOI:10.1039/c3ra00127j

upstream raw materials:

pyridine

deoxybenzoin oxime

benzenesulfonyl chloride

phenylacetic acid

Downstream raw materials:

glycosminine

1,4-diphenyl-pyrrolidine-2,3,5-trione

N⁴-Phenylacetyl-anthranilamid

2,6-dimethylbenzamide

Refernces

• 1、 -. "Efficient nitriding reagent and application thereof". Paragraph 0186-0189. . Retrieved 2021/03/31.
• 2、 Li, Min-Xin,Li, Mei-Ling,Tang, Yan-Ling,Sun, Yun,Qu, Lu,Huang, Feng,Mao, Ze-Wei. "Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source". supporting information. . Retrieved 2021/05/03.