4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride

Base Information

• Chemical Name: 4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride
• CAS No.: 16426-44-1
• Molecular Formula: C₁₀H₁₄N₂O*2ClH
• Molecular Weight: 251.156
• Mol file: 16426-44-1.mol

Synonyms:

Chemical Property of 4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride

There total 8 articles about 4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-methyl-3-nicotinoyl-2-pyrrolidone (125630-28-6) → 4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride (16426-44-1,66093-90-1)

Guidance literature:

With hydrogenchloride; for 72h; Heating;

DOI:10.1016/S0040-4020(01)81978-5

Reference yield: 45.0%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 3-pyridinecarboxylic acid ethyl ester (614-18-6) → 4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride (16426-44-1,66093-90-1)

Guidance literature:

1-methyl-pyrrolidin-2-one; 3-pyridinecarboxylic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; for 24h; Reflux;

With hydrogenchloride; In water; for 72h; Reflux;

Reference yield:

→ 4-(methylamino)-1-(3'-pyridyl)-1-butanone dihydrochloride (16426-44-1,66093-90-1)

Guidance literature:

With hydrogenchloride; at 140 ℃;

DOI:10.1021/ja01160a081

upstream raw materials:

1'-(3-Pyridyl)-4'-(N'-acetylmethylamino)-1'-propanon

(S)-2-methyl-6-[3]pyridyl-tetrahydro-[1,2]oxazine

1-methyl-pyrrolidin-2-one

3-pyridinecarboxylic acid ethyl ester

Downstream raw materials:

D-nicotine

nicotin

1'-(3-Pyridyl)-4'-(N'-acetylmethylamino)-1'-propanon

4-(N-methyl-N-nitrosoamino)-1-(3-pyridyl)-1-butanone

Refernces

• 1、 Haines,Eisner. "-". . p. 1719. Retrieved 1950.
• 2、 Pathak, Tanmaya,Thomas, Noel F.,Akhtar, Mahmoud,Gani, David. "Synthesis of [4-2H2]-, (4R)[4-2H1]-and (4S)[4-2H1]- 4-(methylnitrosamino)-1 -(3′-pyridyl)-1-butanone, c-4 deuteriated isotopomers of the procarcinogen nnk". . p. 1733 - 1744. Retrieved 2007/10/02.