Chloroquine diphosphate

Base Information

• Chemical Name: Chloroquine diphosphate
• CAS No.: 69698-56-2
• Molecular Formula: C₁₈H₂₆ClN₃*H₃O₄P
• Molecular Weight: 417.873
• Mol file: 69698-56-2.mol

Synonyms:

Chemical Property of Chloroquine diphosphate

Chemical Property:

• Vapor Pressure: 1.15E-08mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn:Harmful
• Statements: R22:
• Safety Statements: S22:; S24/25:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Chloroquine diphosphate

There total 24 articles about Chloroquine diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(+)-Chloroquine → (S)-(+)-chloroquine phosphate (69698-56-2)

Guidance literature:

With phosphoric acid; In methanol; for 1h; Reflux;

Reference yield: 86.0%

(R)-(-)-chloroquine (54-05-7,56598-66-4,58175-86-3,58175-87-4) → (R)-chloroquine phosphate (69698-56-2)

Guidance literature:

With phosphoric acid; In ethanol; for 2h; Reflux;

Reference yield: 80.32%

Chloroquine (54-05-7) → chloroquine phosphate (50-63-5,69698-56-2)

Guidance literature:

With phosphoric acid; In ethanol;

upstream raw materials:

Chloroquine

chloroquine phosphate

5-diethylamino-2-pentanone

4,7-dichloroquinoline

Refernces

• 1、 -. "Preparation method of chloroquine phosphate". Paragraph 0030; 0037-0038; 0039; 0046-0047; 0048; 0055-0056. . Retrieved 2021/05/26.
• 2、 -. "Application of L-chiral chloroquine phosphate in preparation of medicine for treating coronavirus". Page/Page column 0016; 0023-0024; 0034; 0040-0041. . Retrieved 2021/09/08.