4-Acetamido-1-acetyl-2-methylimidazole

Base Information

• Chemical Name: 4-Acetamido-1-acetyl-2-methylimidazole
• CAS No.: 58216-76-5
• Molecular Formula: C₈H₁₁N₃O₂
• Molecular Weight: 181.194
• Mol file: 58216-76-5.mol

Synonyms:

Chemical Property of 4-Acetamido-1-acetyl-2-methylimidazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Acetamido-1-acetyl-2-methylimidazole

There total 3 articles about 4-Acetamido-1-acetyl-2-methylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

acetic anhydride (108-24-7) + 2-methyl-4-nitro-1H-imidazole (696-23-1) → 4-Acetamido-1-acetyl-2-methylimidazole (58216-76-5)

Guidance literature:

ShPAK-0.5; In acetic acid; at 25 - 28 ℃; under 7355.08 Torr;

DOI:10.1023/A:1015586205191

Reference yield: 10.0%

acetic anhydride (108-24-7) + 2-methyl-4-nitro-1H-imidazole (696-23-1) → 4,4'-Diacetamido-2,2'-dimethyl-5,5'-biimidazole (145799-26-4) + 4-Acetamido-1-acetyl-2-methylimidazole (58216-76-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; under 760 Torr;

Reference yield:

→ 4-Acetamido-1-acetyl-2-methylimidazole (58216-76-5)

Guidance literature:

Imidazol IIIa, Ra-Ni/H2/(CH3CO)2O;

upstream raw materials:

acetic anhydride

2-methyl-4-nitro-1H-imidazole

Refernces

• 1、 Al-Shaar, Adnan H. M.,Gilmour, David W.,Lythgoe, David J.,McClenaghan, Ian,Ramsden, Christopher A.. "Preparation, Structure and Addition Reactions of 4- and 5-Aminoimidazoles". . p. 2779 - 2788. Retrieved 2007/10/02.