Doxpicomine

Base Information

• Chemical Name: Doxpicomine
• CAS No.: 62904-71-6
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.287
• Mol file: 62904-71-6.mol

Synonyms:

Chemical Property of Doxpicomine

Chemical Property:

• Boiling Point: 319.1±27.0 °C(Predicted)
• PKA: 7.31±0.50(Predicted)
• Density: 1.105±0.06 g/cm3(Predicted)

Purity/Quality:

95-99% ^*data from raw suppliers

DOXPICOMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Analgesic.

Technology Process of Doxpicomine

There total 4 articles about Doxpicomine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dioxan-5-yl pyridin-3-yl ketone (85727-04-4) → (R)-(-)-α-(1,3-dioxan-5-yl)-N,N-dimethyl-3-pyridinemethanamine (62904-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 55.5 g / Et₃N, TiCl₄ / CH₂Cl₂ / 5.5 h / Ambient temperature

2: NaBH₄ / methanol / 6.5 h / -40 °C

3: 8.15 g / 90percent formic acid / 24 h / Heating

With sodium tetrahydroborate; formic acid; titanium tetrachloride; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo00207a037

Reference yield:

(S)-(-)-N-<(1,3-dioxan-5-yl)(3-pyridyl)methylene>-α-methylbenzylamine (94844-55-0) → (R)-(-)-α-(1,3-dioxan-5-yl)-N,N-dimethyl-3-pyridinemethanamine (62904-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 6.5 h / -40 °C

2: 8.15 g / 90percent formic acid / 24 h / Heating

With sodium tetrahydroborate; formic acid; In methanol;

DOI:10.1021/jo00207a037

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-α-(1,3-dioxan-5-yl)-3-pyridinemethanamine dihydrochloride (94903-53-4) → (R)-(-)-α-(1,3-dioxan-5-yl)-N,N-dimethyl-3-pyridinemethanamine (62904-71-6)

Guidance literature:

With formic acid; In methanol; ammonium hydroxide; water; for 18h; Heating;

DOI:10.1021/jo00207a037

upstream raw materials:

formaldehyd

(R)-α-(1,3-dioxan-5-yl)-3-pyridinemethanamine dihydrochloride

(R,S)-α-(1,3-dioxan-5-yl)-N-(1-phenylethyl)-3-pyridinemethanamine

1,3-dioxan-5-yl pyridin-3-yl ketone

Refernces