tert-Butyl 4-(4-aminobutyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(4-aminobutyl)piperidine-1-carboxylate
• CAS No.: 201034-98-2
• Molecular Formula: C₁₄H₂₈N₂O₂
• Molecular Weight: 256.389
• European Community (EC) Number: 856-056-9
• Mol file: 201034-98-2.mol

Synonyms:tert-Butyl 4-(4-aminobutyl)piperidine-1-carboxylate;201034-98-2;1-N-Boc-4-(4-aminobutyl)piperidine;SCHEMBL3044013;HHOFUZXTBHKGTC-UHFFFAOYSA-N;BIA03498;AKOS040768681;DB-115381;CS-0356348;EN300-321407;F80229;4-(1-tert-butoxycarbonylpiperidin-4-yl)butylamine;4-(1-tert-butoxycarbonylpiperidin-4-yl)-butylamine;tert-Butyl4-(4-aminobutyl)piperidine-1-carboxylate;4-(4-Amino-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of tert-Butyl 4-(4-aminobutyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 347.9±15.0 °C(Predicted)
• Density: 0.990±0.06 g/cm3(Predicted)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 256.215078140
• Heavy Atom Count: 18
• Complexity: 253

Purity/Quality:

99% ^*data from raw suppliers

1-BOC-4-(4-AMINOBUTYL)PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)CCCCN

Technology Process of tert-Butyl 4-(4-aminobutyl)piperidine-1-carboxylate

There total 8 articles about tert-Butyl 4-(4-aminobutyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(3-cyanopropyl)piperidine-1-carboxylate (203663-17-6) → tert-butyl 4-(4-aminobutyl)piperidine-1-carboxylate (201034-98-2)

Guidance literature:

With ammonia; hydrogen; Raney Ni; In methanol; water; for 4h; under 2585.81 Torr;

Reference yield: 85.6%

tert-butyl 4-(4-(1,3-dioxoisoindolin-2-yl)butyl)piperidine-1-carboxylate (201034-97-1) → tert-butyl 4-(4-aminobutyl)piperidine-1-carboxylate (201034-98-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 85 ℃; for 2h; Inert atmosphere;

Reference yield:

N-Boc-piperidin-4-yl-propanol (156185-63-6) → tert-butyl 4-(4-aminobutyl)piperidine-1-carboxylate (201034-98-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 0 - 10 °C

2: N,N-dimethyl-formamide / 85 °C

3: hydrogen; ammonia / Raney Ni / water; methanol / 4 h / 2585.81 Torr

With ammonia; hydrogen; triethylamine; Raney Ni; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 4-(3-cyanopropyl)piperidine-1-carboxylate

N-Boc-piperidin-4-yl-propanol

4-(3-Methanesulfonyloxy-propyl)-piperidine-1-carboxylic acid tert-butyl ester

4-(piperidin-4-yl)butan-1-ol

Refernces

• 1、 -. "PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE". . . Retrieved 2018/04/27.
• 2、 -. "NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS". Page/Page column 26. . Retrieved 2008/12/05.