(2R,5S)-2-[4-[4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-phenyl]phenyl]-5-propyl-tetrahydropyran

Base Information

• Chemical Name: (2R,5S)-2-[4-[4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-phenyl]phenyl]-5-propyl-tetrahydropyran
• CAS No.: 700863-48-5
• Molecular Formula: C₂₇H₂₃F₇O₂
• Molecular Weight: 512.467
• Mol file: 700863-48-5.mol

Synonyms:

Chemical Property of (2R,5S)-2-[4-[4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-phenyl]phenyl]-5-propyl-tetrahydropyran

Chemical Property:

• Vapor Pressure: 1.92E-10mmHg at 25°C
• Melting Point: 75℃
• Refractive Index: 0.1450
• Boiling Point: 300-315℃ at 101.33kPa
• Density: 1.409

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,5S)-2-[4-[4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-phenyl]phenyl]-5-propyl-tetrahydropyran

There total 1 articles about (2R,5S)-2-[4-[4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-phenyl]phenyl]-5-propyl-tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

{4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl}boronic acid (685563-69-3) + C14H19BrO → C27H23F7O2 (700863-48-5)

Guidance literature:

With sodium borate; palladium triphenylphosphine dichloride; hydrazine hydrate; In tetrahydrofuran; water; for 18h; Reflux;

DOI:10.1002/ejoc.200800149

upstream raw materials:

{4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl}boronic acid

Refernces