Technology Process of 6-O-<(2RS,3SR)-3-hydroxy-2-tetradecyloctadecanoyl>-α,α-trehalose
There total 10 articles about 6-O-<(2RS,3SR)-3-hydroxy-2-tetradecyloctadecanoyl>-α,α-trehalose which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: imidazole / dimethylformamide; toluene / 75 °C
2: 78 percent / 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine, molecular sieves 4A / toluene / 1) 0 to 25 deg C, 4-6 h, 2) 60-70 deg C, 6-8 h
3: 1) 0.5percent methanolic K2CO3, 2) M tetrabutylammonium fluoride, CF3COOH / 1) CHCl3, RT, 3-4 h, 2) oxolane, RT, 1.5 h
With
1H-imidazole; dmap; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
N,N-dimethyl-formamide; toluene;
DOI:10.1016/0008-6215(91)84089-W
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 5percent KOH / butan-1-ol; H2O / Heating
2: imidazole / dimethylformamide; toluene / 75 °C
3: 78 percent / 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine, molecular sieves 4A / toluene / 1) 0 to 25 deg C, 4-6 h, 2) 60-70 deg C, 6-8 h
4: 1) 0.5percent methanolic K2CO3, 2) M tetrabutylammonium fluoride, CF3COOH / 1) CHCl3, RT, 3-4 h, 2) oxolane, RT, 1.5 h
With
1H-imidazole; dmap; potassium hydroxide; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
water; N,N-dimethyl-formamide; toluene; butan-1-ol;
DOI:10.1016/0008-6215(91)84089-W
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98.5 percent / xylene / 5 h / 145 °C
2: 54 percent / NaBH4 / CHCl3; methanol / 4 h / Ambient temperature
3: 5percent KOH / butan-1-ol; H2O / Heating
4: imidazole / dimethylformamide; toluene / 75 °C
5: 78 percent / 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine, molecular sieves 4A / toluene / 1) 0 to 25 deg C, 4-6 h, 2) 60-70 deg C, 6-8 h
6: 1) 0.5percent methanolic K2CO3, 2) M tetrabutylammonium fluoride, CF3COOH / 1) CHCl3, RT, 3-4 h, 2) oxolane, RT, 1.5 h
With
1H-imidazole; dmap; potassium hydroxide; sodium tetrahydroborate; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
methanol; chloroform; water; N,N-dimethyl-formamide; toluene; xylene; butan-1-ol;
DOI:10.1016/0008-6215(91)84089-W