3-acetyl-2-hydroxy-4-methoxy-benzaldehyde

Base Information

• Chemical Name: 3-acetyl-2-hydroxy-4-methoxy-benzaldehyde
• CAS No.: 412022-08-3
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.187
• Mol file: 412022-08-3.mol

Synonyms:

Chemical Property of 3-acetyl-2-hydroxy-4-methoxy-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetyl-2-hydroxy-4-methoxy-benzaldehyde

There total 2 articles about 3-acetyl-2-hydroxy-4-methoxy-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-hydroxy-6'-methoxyacetophenone (703-23-1) → 3-acetyl-2-hydroxy-4-methoxy-benzaldehyde (412022-08-3)

Guidance literature:

With hydrogenchloride; aluminium trichloride; diethyl ether; Erwaermen des Reaktionsprodukts mit Wasser;

Reference yield:

hydrogen cyanide (74-90-8) + 2'-hydroxy-6'-methoxyacetophenone (703-23-1) → 3-acetyl-2-hydroxy-4-methoxy-benzaldehyde (412022-08-3)

Guidance literature:

With hydrogenchloride; aluminium trichloride; diethyl ether; Erwaermen des Reaktionsprodukts mit Wasser;

DOI:10.1039/jr9480002138

Reference yield:

3-acetyl-2-hydroxy-4-methoxy-benzaldehyde (412022-08-3) → primetin (548-58-3)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH solution; aqueous H₂O₂

2: sodium benzoate / 180 °C

3: concentrated sulfuric acid

4: aluminium chloride; nitrobenzene

With sodium benzoate; sodium hydroxide; aluminium trichloride; sulfuric acid; dihydrogen peroxide; nitrobenzene;

upstream raw materials:

hydrogen cyanide

2'-hydroxy-6'-methoxyacetophenone

Downstream raw materials:

1-(2,3-dihydroxy-6-methoxy-phenyl)-ethanone

5,8-dihydroxy-2-(4-methoxy-phenyl)-chromen-4-one

8-hydroxy-5-methoxy-2-(4-methoxy-phenyl)-chromen-4-one

primetin