Technology Process of (-)-(1S,2R,3R,4S)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,h]anthracene
There total 5 articles about (-)-(1S,2R,3R,4S)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,h]anthracene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
161906-53-2,86541-62-0
(-)-(1S,2R,3R,4S)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,h]anthracene
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
DOI:10.1021/tx200398b
-
-
161906-53-2,86541-62-0
(-)-(1S,2R,3R,4S)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,h]anthracene
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 0.67 h / 60 °C / UV-irradiation; Reflux
2.1: lithium carbonate; lithium chloride / N,N,N,N,N,N-hexamethylphosphoric triamide / 2.5 h / 100 °C / Inert atmosphere
3.1: methanol
4.1: silica-bound (-)-2-(2,5,9,11-tetranitro-7H-benzo[c]fluoren-7-ylideneaminooxy)propionic acid / methanol; dichloromethane / Resolution of racemate
4.2: silica-bound (+)-2-(2,5,9,11-tetranitro-7H-benzo[c]fluoren-7-ylideneaminooxy)propionic acid / Resolution of racemate
5.1: 3-chloro-benzenecarboperoxoic acid
With
methanol; N-Bromosuccinimide; lithium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium chloride; dibenzoyl peroxide;
In
methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/tx200398b
-
-
161906-53-2,86541-62-0
(-)-(1S,2R,3R,4S)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,h]anthracene
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanol
2.1: silica-bound (-)-2-(2,5,9,11-tetranitro-7H-benzo[c]fluoren-7-ylideneaminooxy)propionic acid / methanol; dichloromethane / Resolution of racemate
2.2: silica-bound (+)-2-(2,5,9,11-tetranitro-7H-benzo[c]fluoren-7-ylideneaminooxy)propionic acid / Resolution of racemate
3.1: 3-chloro-benzenecarboperoxoic acid
With
methanol; 3-chloro-benzenecarboperoxoic acid;
In
methanol; dichloromethane;
DOI:10.1021/tx200398b