(R,S,S,S)-Nebivolol Hydrochloride

Base Information

• Chemical Name: (R,S,S,S)-Nebivolol Hydrochloride
• CAS No.: 920299-33-8
• Molecular Formula: C₂₂H₂₅F₂NO₄*ClH
• Molecular Weight: 441.903
• Mol file: 920299-33-8.mol

Synonyms:

Chemical Property of (R,S,S,S)-Nebivolol Hydrochloride

Chemical Property:

Purity/Quality:

(R,S,S,S)-NebivololHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (R,S,S,S)-Nebivolol Hydrochloride is a β1-Adrenergic blocker. Used as an antihypertensive.

Technology Process of (R,S,S,S)-Nebivolol Hydrochloride

There total 125 articles about (R,S,S,S)-Nebivolol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-((R)-6-fluoro-chroman-2-yl)-ethyl]-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-((S)-6-fluoro-chroman-2-yl)-ethyl]-amine (212909-96-1) → d-nebivolol hydrochloride (152520-56-4,920299-33-8)

Guidance literature:

With hydrogenchloride; In methanol; for 12h;

DOI:10.1021/ja981378o

Reference yield: 97.24%

nebivolol (99200-09-6,118457-14-0,118457-15-1,119365-25-2,119365-23-0,1360598-84-0) → DL-nebivolol hydrochloride (152520-56-4,920299-33-8)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 28 - 32 ℃; for 4h; Product distribution / selectivity;

Reference yield: 95.0%

N-benzylnebivolol (929706-85-4) → nebivolol hydrochloride (169293-50-9,152520-56-4,920299-33-8)

Guidance literature:

N-benzylnebivolol; With 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In water; for 12h; Large scale;

With sodium chloride; In water; for 8h; Large scale;

upstream raw materials:

[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-((R)-6-fluoro-chroman-2-yl)-ethyl]-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-((S)-6-fluoro-chroman-2-yl)-ethyl]-amine

6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran

(R)-2-amino-1-[(S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol

4-Fluorophenol

Refernces

• 1、 -. "NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF". Paragraph 0085; 0161; 0411-0413. . Retrieved 2018/06/04.
• 2、 -. "PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL". Page/Page column 38-39. . Retrieved 2017/08/20.