O-TriphenylMethoxy Quetiapine

Base Information

• Chemical Name: O-TriphenylMethoxy Quetiapine
• CAS No.: 844639-06-1
• Molecular Formula: C₄₀H₃₉N₃O₂S
• Molecular Weight: 625.835
• Mol file: 844639-06-1.mol

Synonyms:

Chemical Property of O-TriphenylMethoxy Quetiapine

Chemical Property:

• Melting Point: >74°C (dec.)
• Boiling Point: 725.2±70.0 °C(Predicted)
• PKA: 6.78±0.10(Predicted)
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

O-TriphenylmethoxyQuetiapine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: O-Triphenylmethoxy Quetiapine is an impurity of Quetiapine hemifumarate (Q510000), a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia.

Technology Process of O-TriphenylMethoxy Quetiapine

There total 1 articles about O-TriphenylMethoxy Quetiapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

O-Dealkyl Quetiapine (329216-67-3) + 2-triphenylmethoxy-1-chloroethane (1235-23-0) → 11-{4-[2-(2-tritiloxiethoxy)ethyl]piperazine-1-yl}dibenzo[b,f][1,4]thiazepine (844639-06-1)

Guidance literature:

O-Dealkyl Quetiapine; 2-triphenylmethoxy-1-chloroethane; at 100 - 110 ℃;

With potassium hydroxide; at 110 - 115 ℃; for 0.75 - 1h;

18-crown-6 ether; at 110 - 115 ℃; for 2h;

upstream raw materials:

O-Dealkyl Quetiapine

2-triphenylmethoxy-1-chloroethane

Refernces