1-[2-(4-METHOXYPHENYL)-2-OXOETHYL]CYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-[2-(4-METHOXYPHENYL)-2-OXOETHYL]CYCLOHEXANECARBOXYLIC ACID
• CAS No.: 887571-46-2
• Molecular Formula: C₁₆H₂₀O₄
• Molecular Weight: 276.332
• Mol file: 887571-46-2.mol

Synonyms:

Chemical Property of 1-[2-(4-METHOXYPHENYL)-2-OXOETHYL]CYCLOHEXANECARBOXYLIC ACID

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(4-METHOXYPHENYL)-2-OXOETHYL]CYCLOHEXANECARBOXYLIC ACID

There total 6 articles about 1-[2-(4-METHOXYPHENYL)-2-OXOETHYL]CYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methoxybenzene (100-66-3) + cyclohexan-1-acetic-1-carboxylic anhydride (6051-25-8) → 1-(2-(4-methoxyphenyl)-2-oxoethyl)cyclohexancarboxylic acid (887571-46-2)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 26 ℃; for 12h; Inert atmosphere;

DOI:10.2174/1570180816666190710130119

Reference yield:

1-carboxycyclohexylacetic acid (67950-95-2) → 1-(2-(4-methoxyphenyl)-2-oxoethyl)cyclohexancarboxylic acid (887571-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride / 3 h / Reflux

2: aluminum (III) chloride / dichloromethane / 12 h / 0 - 26 °C / Inert atmosphere

With aluminum (III) chloride; acetyl chloride; In dichloromethane; 2: |Friedel-Crafts Acylation;

DOI:10.2174/1570180816666190710130119

Reference yield:

methoxybenzene (100-66-3) + cyclohexan-1-acetic-1-carboxylic anhydride (6051-25-8) → [1-(4-methoxy-benzoyl)-cyclohexyl]-acetic acid (856185-55-2) + 1-(2-(4-methoxyphenyl)-2-oxoethyl)cyclohexancarboxylic acid (887571-46-2)

Guidance literature:

With aluminum (III) chloride; at 0 - 20 ℃; for 24.5h;

DOI:10.3390/molecules26082140

upstream raw materials:

cyclohexanone

ethyl 2-cyano-2-cyclohexylideneacetate

ethyl 2-cyano-2-(1-cyanocyclohexyl)acetate

methoxybenzene

Refernces

• 1、 Für, Csilla Sepsey,Riszter, Gergo,Gerencsér, János,Szigetvári, áron,Dékány, Miklós,Hazai, László,Keglevich, Gy?rgy,B?lcskei, Hedvig. "Synthesis of spiro[cycloalkane-pyridazinones] with high Fsp3 character". . p. 731 - 744. Retrieved 2020/06/22.