C₉H₅ClFNO₂S*ClH

Base Information

• Chemical Name: C₉H₅ClFNO₂S*ClH
• CAS No.: 1334294-10-8
• Molecular Formula: C₉H₅ClFNO₂S*ClH
• Molecular Weight: 282.123
• Mol file: 1334294-10-8.mol

Synonyms:

Chemical Property of C₉H₅ClFNO₂S*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₅ClFNO₂S*ClH

There total 2 articles about C₉H₅ClFNO₂S*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4--fluoroisoquinoline (394-67-2) → C9H5ClFNO2S*ClH (1334294-10-8) + 4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride (906820-08-4)

Guidance literature:

4--fluoroisoquinoline; With sulfuric acid; at 10 - 40 ℃; for 0.5h;

With sulfur trioxide; at 20 - 45 ℃; for 12h;

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; more than 3 stages; Product distribution / selectivity;

Reference yield: 45.4%

4-fluoroisoquinoline sulfate (906820-09-5) → C9H5ClFNO2S*ClH (1334294-10-8) + 4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride (906820-08-4)

Guidance literature:

4-fluoroisoquinoline sulfate; With sulfur trioxide; at 26 - 34 ℃; for 13h;

With thionyl chloride; at 30 - 70 ℃; for 4h;

With hydrogenchloride; sodium hydrogencarbonate; more than 3 stages; Product distribution / selectivity;

upstream raw materials:

4--fluoroisoquinoline

4-fluoroisoquinoline sulfate

Refernces

• 1、 -. "PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF". Page/Page column 7-8. . Retrieved 2008/06/13.