2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONIC ACID DIMETHYLAMIDE

Base Information

• Chemical Name: 2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONIC ACID DIMETHYLAMIDE
• CAS No.: 81428-07-1
• Molecular Formula: C₁₂H₁₄N₂O₄S
• Molecular Weight: 282.32
• Mol file: 81428-07-1.mol

Synonyms:

Chemical Property of 2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONIC ACID DIMETHYLAMIDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N,N-dimethylethanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONIC ACID DIMETHYLAMIDE

There total 7 articles about 2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONIC ACID DIMETHYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.8%

2-phthalimido-ethanesulfonyl chloride (4403-36-5) + N,N-dimethylammonium chloride (506-59-2) → 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethanesulfonic acid dimethylamide (81428-07-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2015.08.015

Reference yield: 50.0%

2-phthalimido-ethanesulfonyl chloride (4403-36-5) + dimethyl amine (124-40-3) → 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethanesulfonic acid dimethylamide (81428-07-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm901379s

Reference yield: 45.0%

→ 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethanesulfonic acid dimethylamide (81428-07-1)

Guidance literature:

upstream raw materials:

2-phthalimido-ethanesulfonyl chloride

dimethyl amine

phthalic anhydride

NCS 731

Downstream raw materials:

2-amino-N,N-dimethyl-ethanesulfonamide hydrochloride

2-aminoethanesulfonic acid dimethylamide

Refernces

• 1、 -. "ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS". Paragraph 0610-0611. . Retrieved 2020/04/09.
• 2、 Li, Ling,Li, Zheng,Wang, Kailiang,Liu, Yuxiu,Li, Yongqiang,Wang, Qingmin. "Synthesis and antiviral, insecticidal, and fungicidal activities of gossypol derivatives containing alkylimine, oxime or hydrazine moiety". . p. 474 - 483. Retrieved 2016/01/25.