3-bromo-4-iodoquinoline

Base Information

• Chemical Name: 3-bromo-4-iodoquinoline
• CAS No.: 927800-61-1
• Molecular Formula: C₉H₅BrIN
• Molecular Weight: 333.954
• Mol file: 927800-61-1.mol

Synonyms:

Chemical Property of 3-bromo-4-iodoquinoline

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-4-iodoquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4-iodoquinoline

There total 5 articles about 3-bromo-4-iodoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-4-chloroquinoline (74575-17-0) → 3-bromo-4-iodoquinoline (927800-61-1)

Guidance literature:

3-bromo-4-chloroquinoline; With hydrogenchloride; In diethyl ether; dichloromethane; at 5 - 20 ℃; for 1h;

With sodium iodide; In acetonitrile; for 5h; Reflux;

DOI:10.1016/j.tet.2013.08.019

Reference yield:

aniline (62-53-3) → 3-bromo-4-iodoquinoline (927800-61-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 0.5 h / Reflux

1.2: 0.67 h / Reflux

2.1: diphenylether / 0.5 h / 250 °C / Inert atmosphere

3.1: acetic acid / 0.17 h / Reflux

3.2: 2 h / Reflux

4.1: trichlorophosphate / acetonitrile / 7 h / 20 °C / Reflux

5.1: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 5 - 20 °C

5.2: 5 h / Reflux

With hydrogenchloride; acetic acid; trichlorophosphate; In diphenylether; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2013.08.019

Reference yield:

5-(N-phenyl)-aminomethylene-2,2-dimethyl-1,3-dioxane-4,6-dione (15568-92-0) → 3-bromo-4-iodoquinoline (927800-61-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diphenylether / 0.5 h / 250 °C / Inert atmosphere

2.1: acetic acid / 0.17 h / Reflux

2.2: 2 h / Reflux

3.1: trichlorophosphate / acetonitrile / 7 h / 20 °C / Reflux

4.1: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 5 - 20 °C

4.2: 5 h / Reflux

With hydrogenchloride; acetic acid; trichlorophosphate; In diphenylether; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2013.08.019

upstream raw materials:

aniline

5-(N-phenyl)-aminomethylene-2,2-dimethyl-1,3-dioxane-4,6-dione

3-bromoquinolin-4(1H)-one

3-bromo-4-chloroquinoline

Downstream raw materials:

11H-indolo[3,2-c]quinoline

Refernces