Mercapto-β-cyclodextrin

Base Information

• Chemical Name: Mercapto-β-cyclodextrin
• CAS No.: 81644-55-5
• Molecular Formula: C₄₂H₇₀O₃₄S
• Molecular Weight: 1151.06
• Mol file: 81644-55-5.mol

Synonyms:

Chemical Property of Mercapto-β-cyclodextrin

Chemical Property:

• Boiling Point: 1534.4±60.0 °C(Predicted)
• PKA: 9.42±0.10(Predicted)
• Density: 1.609±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Mercapto-6-deoxy-β-Cyclodextrin 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Mercapto-β-cyclodextrin

There total 4 articles about Mercapto-β-cyclodextrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin (67217-55-4) → 6-deoxy-6-mercapto-β-cyclodextrin (81644-55-5)

Guidance literature:

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin; With thiourea; In N,N-dimethyl-formamide; at 75 ℃; for 48h;

With sodium metabisulfite; sodium hydroxide; In water; at 20 ℃; for 0.5h;

With hydrogenchloride; Trichloroethylene; In water; at 20 ℃; for 0.166667h; pH=3; Sonication;

DOI:10.1002/chem.201402418

Reference yield: 69.0%

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin (67217-55-4) + thiourea (17356-08-0) → 6-deoxy-6-mercapto-β-cyclodextrin (81644-55-5)

Guidance literature:

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin; thiourea; In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h; microwave irradiation;

With sodium hydroxide; water; at 20 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.10.104

Reference yield: 50.0%

mono<6-(p-tolylsulfonyl)-6-deoxy>-β-cyclodextrin → 6-deoxy-6-mercapto-β-cyclodextrin (81644-55-5)

Guidance literature:

With thiourea; In methanol; water; at 20 ℃; Reflux;

DOI:10.1021/ol800405b

upstream raw materials:

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin

thiourea

β‐cyclodextrin

Downstream raw materials:

6-deoxy-6-<(3-thym-1-yl)propyl)thio>-β-cyclodextrin

Refernces

• 1、 Martina, Katia,Trotta, Francesco,Robaldo, Bruna,Belliardi, Nikka,Jicsinszky, László,Cravotto, Giancarlo. "Efficient regioselective functionalizations of cyclodextrins carried out under microwaves or power ultrasound". . p. 9185 - 9189. Retrieved 2007.
• 2、 Wang, Li-Yun,Dong, Ling-Yu,Chen, Luan,Fan, Ya-Bing,Wu, Jing,Wang, Xiang-Feng,Xie, Meng-Xia. "A novel water-soluble quantum dot-neutral red fluorescence resonance energy transfer probe for the selective detection of megestrol acetate". . p. 555 - 565. Retrieved 2015.
• 3、 Shen, Ping,Qiu, Liyan. "Dual-responsive recurrent self-assembly of a supramolecular polymer based on the host-guest complexation interaction between β-cyclodextrin and azobenzene". . p. 3593 - 3601. Retrieved 2018/03/06.
• 4、 Fan, Xiaotong,Wang, Liang,Luo, Quan,Zhao, Linlu,Xu, Jiayun,Liu, Junqiu,Zheng, Qingchuan. "Construction of giant branched nanotubes from cyclodextrin-based supramolecular amphiphiles". supporting information. p. 6512 - 6514. Retrieved 2015/04/14.