Methyl (+/-)-trans-4-phenylpyrrolidine-3-carboxylate hydrochloride

Base Information

• Chemical Name: Methyl (+/-)-trans-4-phenylpyrrolidine-3-carboxylate hydrochloride
• CAS No.: 874367-19-8
• Molecular Formula: C₁₂H₁₅NO₂*ClH
• Molecular Weight: 241.718
• Mol file: 874367-19-8.mol

Synonyms:

Chemical Property of Methyl (+/-)-trans-4-phenylpyrrolidine-3-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Methyl(+/-)-trans-4-phenylpyrrolidine-3-carboxylatehydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (+/-)-trans-4-phenylpyrrolidine-3-carboxylate hydrochloride

There total 2 articles about Methyl (+/-)-trans-4-phenylpyrrolidine-3-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H23NO4 (2140264-81-7) → C12H15NO2*ClH (874367-19-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield:

1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid (221142-28-5,884048-45-7,939757-89-8) → C12H15NO2*ClH (874367-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 1 h

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; sodium hydride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

C12H15NO2*ClH (874367-19-8) → C21H24N2O5S

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dimethyl sulfoxide / 1 h / 60 °C

2: sodium hydroxide / water; methanol / 2 h / 20 °C

With triethylamine; sodium hydroxide; In methanol; water; dimethyl sulfoxide;

upstream raw materials:

1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid

C₁₇H₂₃NO₄

Refernces