1-Amino-1,5-dideoxy-L-erythro-2-pentulose

Base Information

• Chemical Name: 1-Amino-1,5-dideoxy-L-erythro-2-pentulose
• CAS No.: 858127-57-8
• Molecular Formula: C₅H₁₁NO₃
• Molecular Weight: 133.147
• Mol file: 858127-57-8.mol

Synonyms:

Chemical Property of 1-Amino-1,5-dideoxy-L-erythro-2-pentulose

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-Amino-1,5-dideoxy-L-erythro-2-pentulose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Amino-1,5-dideoxy-L-erythro-2-pentulose

There total 2 articles about 1-Amino-1,5-dideoxy-L-erythro-2-pentulose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4S,5S)-2,2,5-trimethyl-5-(2-azidoacetyl)-1,3-dioxolane → (3S,4S)-1-amino-3,4-dihydroxy-2-pentanone (858127-57-8)

Guidance literature:

With triphenylphosphine; citric acid; In tetrahydrofuran; water; acetone; at 20 ℃; for 8h; pH=3; Reagent/catalyst; Solvent; Temperature; Large scale;

Reference yield:

(4S,5S)-2,2,5-trimethyl-5-chloroacetyl-1,3-dioxolane → (3S,4S)-1-amino-3,4-dihydroxy-2-pentanone (858127-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; sodium iodide / acetone / 25 h / 30 °C / Large scale

2: triphenylphosphine; citric acid / water; tetrahydrofuran; acetone / 8 h / 20 °C / pH 3 / Large scale

With sodium azide; triphenylphosphine; citric acid; sodium iodide; In tetrahydrofuran; water; acetone;

Reference yield:

(3S,4S)-1-amino-3,4-dihydroxy-2-pentanone (858127-57-8) → Sapropterin dihydrochloride (69056-38-8,69056-39-9,71074-53-8,83023-72-7,83709-59-5,90366-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium iodide; triethylamine / water; isopropyl alcohol / 6 h / 50 °C / Large scale

2.1: hydrogen; 5%-palladium/activated carbon / methanol / 22 h / 25 °C / 6000.6 Torr / Autoclave; Large scale

3.1: hydrogen; palladium on carbon / water / 80 h / 20 °C / 4500.45 Torr / Large scale

3.2: Large scale

With 5%-palladium/activated carbon; palladium on carbon; hydrogen; triethylamine; sodium iodide; In methanol; water; isopropyl alcohol;

Downstream raw materials:

Sapropterin dihydrochloride

Refernces

• 1、 -. "METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE". . . Retrieved 2015/04/22.
• 2、 -. "METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE". Paragraph 0028. . Retrieved 2015/03/03.