11-Nor-Δ9-Tetrahydro Cannabinol-9-carboxylic Acid

Base Information

• Chemical Name: 11-Nor-Δ9-Tetrahydro Cannabinol-9-carboxylic Acid
• CAS No.: 96912-65-1
• Molecular Formula: C₁₉H₂₄O₄
• Molecular Weight: 316.397
• Mol file: 96912-65-1.mol

Synonyms:

Chemical Property of 11-Nor-Δ9-Tetrahydro Cannabinol-9-carboxylic Acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 11-Nor-Δ9-Tetrahydro Cannabinol-9-carboxylic Acid

Technology Process of 11-Nor-Δ9-Tetrahydro Cannabinol-9-carboxylic Acid

There total 4 articles about 11-Nor-Δ9-Tetrahydro Cannabinol-9-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-O-acetyl-Δ9-tetrahydrocannabivarin-11-oic acid → Δ9-tetrahydrocannabivarin-11-oic acid (96912-65-1)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 1h;

DOI:10.1021/acs.jnatprod.9b00831

Reference yield:

tetrahydrocannabivarin (31262-37-0,28172-17-0) → Δ9-tetrahydrocannabivarin-11-oic acid (96912-65-1)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 18 h / 20 °C

2: selenium(IV) oxide / ethanol / 1.25 h / Reflux

3: manganese(IV) oxide / diethyl ether / 0 - 20 °C

4: sodium chlorite; 2-methyl-but-2-ene; potassium dihydrogenphosphate / water; tert-butyl alcohol / 20 °C

5: sodium hydroxide / methanol; water / 1 h / 20 °C

With pyridine; manganese(IV) oxide; selenium(IV) oxide; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydroxide; In methanol; diethyl ether; ethanol; water; tert-butyl alcohol;

DOI:10.1021/acs.jnatprod.9b00831

Reference yield:

1-O-acetyl-Δ9-tetrahydrocannabivarin → Δ9-tetrahydrocannabivarin-11-oic acid (96912-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: selenium(IV) oxide / ethanol / 1.25 h / Reflux

2: manganese(IV) oxide / diethyl ether / 0 - 20 °C

3: sodium chlorite; 2-methyl-but-2-ene; potassium dihydrogenphosphate / water; tert-butyl alcohol / 20 °C

4: sodium hydroxide / methanol; water / 1 h / 20 °C

With manganese(IV) oxide; selenium(IV) oxide; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydroxide; In methanol; diethyl ether; ethanol; water; tert-butyl alcohol;

DOI:10.1021/acs.jnatprod.9b00831

upstream raw materials:

tetrahydrocannabivarin

Refernces