(2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide

Base Information

• Chemical Name: (2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide
• CAS No.: 370-55-8
• Molecular Formula: C₈H₆F₂N₂O₂
• Molecular Weight: 200.145
• Mol file: 370-55-8.mol

Synonyms:

Chemical Property of (2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide

There total 1 articles about (2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloral hydrate (302-17-0) + 3,4-difluoroaniline (3863-11-4) → (2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide (370-55-8)

Guidance literature:

With hydrogenchloride; hydroxylamine; sodium sulfate;

DOI:10.1021/jo01106a010

Reference yield: 86.0%

(2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide (370-55-8) → 5,6-difluoro-1H-indole-2,3-dione (774-47-0)

Guidance literature:

With sulfuric acid; In water; at 60 - 80 ℃; for 0.5h; regioselective reaction; Inert atmosphere;

DOI:10.1055/s-0035-1561395

upstream raw materials:

chloral hydrate

3,4-difluoroaniline

Downstream raw materials:

5,6-difluoro-1H-indole-2,3-dione