C₂₄H₃₅F₂N₅O

Base Information

• Chemical Name: C₂₄H₃₅F₂N₅O
• CAS No.: 1309869-64-4
• Molecular Formula: C₂₄H₃₅F₂N₅O
• Molecular Weight: 447.572
• Mol file: 1309869-64-4.mol

Synonyms:

Chemical Property of C₂₄H₃₅F₂N₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₃₅F₂N₅O

There total 8 articles about C₂₄H₃₅F₂N₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester (865774-07-8) → C24H35F2N5O (1309869-64-4)

Guidance literature:

Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / dichloromethane / -30 °C

2: dichloromethane / Molecular sieve

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

4: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.118

Reference yield:

2-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehyde (865774-76-1) → C24H35F2N5O (1309869-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / Molecular sieve

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

3: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.118

Reference yield:

6,8-difluoro-3,4-dihydronaphthalen-2(1H)-one (843644-23-5) → C24H35F2N5O (1309869-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane

2: hydrogenchloride; water

3: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.118

upstream raw materials:

2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester

2-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehyde

6,8-difluoro-3,4-dihydronaphthalen-2(1H)-one

C₁₉H₂₇F₂NO₂

Refernces