(3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt

Base Information

• Chemical Name: (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt
• CAS No.: 919364-56-0
• Molecular Formula: C₄H₆O₆*C₆H₁₃NO₃
• Molecular Weight: 297.262
• Mol file: 919364-56-0.mol

Synonyms:

Chemical Property of (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt

There total 4 articles about (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt (919364-56-0,957230-65-8)

Guidance literature:

Purification / work up;

Reference yield: 48.0%

L-Tartaric acid (87-69-4,138508-61-9) + (3R,4R,5S,6S)-6-(benzyloxy)-4,5-dihydroxytetrahydro-2H-pyran-3-carbonitrile (1084896-41-2) → (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt (919364-56-0,957230-65-8)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol; water; at 30 ℃; for 24h; under 4137.29 Torr; Product distribution / selectivity;

Reference yield:

L-Tartaric acid (87-69-4,138508-61-9) → (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol L-(+)-tartrate salt (919364-56-0,957230-65-8)

Guidance literature:

(3R,4R,5S,6S)-4,5,6-Tris(benzyloxy)tetrahydro-2H-pyran-3-carbonitrile; With hydrogenchloride; hydrogen; palladium dihydroxide; palladium 10% on activated carbon; In ethanol; water; at 35 ℃; for 72h; under 4137.29 Torr;

With ammonia; In ethanol; water;

L-Tartaric acid; In ethanol; for 0.75h;

upstream raw materials:

L-Tartaric acid

isofagomine

(3R,4R,5S,6S)-6-(benzyloxy)-4,5-dihydroxytetrahydro-2H-pyran-3-carbonitrile

Refernces

• 1、 -. "Tartrate sale of isofagomine and methods of use". Page/Page column 16. . Retrieved 2008/06/13.